Synovial biomarkers in psoriatic arthritis
| Autor: | Antonio Di Maggio, Leonardo Punzi, Paolo Sfriso, Leopoldo Rubaltelli, Benedetta Accordi, Jean-Michel Dayer, Fiorella Calabrese, Francesca Oliviero, Ugo Fiocco, R. Nardacchione, Katia Gazzola, Roberto Stramare, Mara Felicetti, Alessandro Lo Nigro, Beatrice Molena, Francesca Lunardi, Pascale Roux-Lombard, L Cozzi, Elena Scagliori |
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| Rok vydání: | 2012 |
| Předmět: |
Questionnaires
Male Pathology Time Factors Biological Markers/metabolism Knee Joint Biopsy Interleukin-6/metabolism Interleukin-1beta Arthritis Gastroenterology Immunoglobulin G/administration & dosage Synovial Fluid/metabolism Receptors Tumor Necrosis Factor Etanercept Injections Intra-Articular Disability Evaluation Surveys and Questionnaires Receptors Synovial Fluid Ultrasonography ddc:616 medicine.diagnostic_test Synovial Membrane CD/metabolism Endoglin General Medicine Middle Aged Immunohistochemistry Magnetic Resonance Imaging Platelet Endothelial Cell Adhesion Molecule-1 C-Reactive Protein Treatment Outcome CD45/metabolism Female Immunosuppressive Agents medicine.drug musculoskeletal diseases Psoriatic/diagnosis/drug therapy/metabolism Adult medicine.medical_specialty Intra-Articular Cell Surface/metabolism Receptors Cell Surface Drug Administration Schedule Injections Psoriatic arthritis Antigens CD Synovitis Internal medicine Tumor Necrosis Factor/administration & dosage medicine Synovial fluid Humans Antigens Immunosuppressive Agents/administration & dosage CD31/metabolism Knee Joint/drug effects/metabolism/pathology/ultrasonography business.industry Interleukin-6 C-Reactive Protein/metabolism Arthritis Psoriatic Magnetic resonance imaging medicine.disease Synovial Membrane/drug effects/metabolism/pathology/ultrasonography Interleukin 1 Receptor Antagonist Protein Immunoglobulin G Interleukin-1beta/metabolism Leukocyte Common Antigens business Biomarkers Interleukin 1 Receptor Antagonist Protein/metabolism |
| Zdroj: | Journal of Rheumatology, Vol. 89 (2012) pp. 61-4 |
| ISSN: | 0380-0903 0315-162X |
| Popis: | Objective. To find candidate biomarkers of psoriatic arthritis (PsA). A panel of synovial fluid (SF) and synovial tissue (ST) biomarkers was analyzed in patients with resistant peripheral PsA, in relation to clinical and imaging outcomes of synovitis response following serial intraarticular (IA) etanercept injections (12.5 mg). Methods. Fourteen PsA patients with resistant knee joint synovitis were treated with 4 IA etanercept injections in a single knee joint, once every 2 weeks. Primary outcome (Thompson’s knee index: THOMP) and secondary outcomes were assessed at baseline and end of study: C-reactive protein, Knee Joint Articular Index (KJAI), Health Assessment Questionnaire disability index, maximal synovial thickness (MST) by gray-scale ultrasonography, contrast-enhanced magnetic resonance imaging (C+MRI), ST-cluster differentiation (CD)45+ mononuclear cell, ST-CD31+ vessels, and ST-CD105+ angiogenic endothelial cells, along with levels of SF interleukin 1s (IL-1s), IL-1 receptor antagonist (Ra), and IL-6. Results. At the end of the study, clinical and imaging outcomes, ST and SF biological markers were significantly reduced compared to baseline. There was a significant association between IL-6 and either THOMP or KJAI; between either ST-CD31+ or ST-CD105+ or ST-CD45+; between ST and SF biomarkers expression (CD45+ and IL-1s) and between ST-CD45+ and both KJAI and MRI-MST. Comparing pre- versus post-IA etanercept injection changes (Δ), Δ IL-1s was significantly correlated with both Δ IL-6 and with Δ IL-1Ra and Δ IL-6 with Δ IL-1Ra. Conclusion. The association to disease activity and the changes following IA treatment indicate that ST-CD45+ and ST-CD31+, along with SF-IL-6 and SF-IL-1s, may represent candidate biomarkers of the knee synovitis response to IA tumor necrosis factor-α blockade. |
| Databáze: | OpenAIRE |
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