Renin-angiotensin system microRNAs:special focus on the brain
| Autor: | Jose G. Gerardo-Aviles, Shelley J Allen, Patrick G. Kehoe |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Focus (computing) business.industry Bioinformatics Brain renin-angiotensin system Non-coding RNAs 03 medical and health sciences Circulating MicroRNA MicroRNAs 030104 developmental biology 0302 clinical medicine Endocrinology Internal medicine Circulating microRNAs Renin–angiotensin system microRNA medicine business Cerebrovascular disease 030217 neurology & neurosurgery Biomarkers |
| Zdroj: | Gerardo-Aviles, J, Allen-Birt, S & Kehoe, P 2017, Renin-angiotensin system microRNAs : special focus on the brain . in Renin-angiotensin system : past, present and future . Croatia . https://doi.org/10.5772/67080 |
| Popis: | MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression with important roles in cancer, cardiovascular and neurological disorders. Present in the brain, they play numerous regulatory roles shaping the proteome in an orchestrated manner with other non-coding RNAs.An independent brain-specific renin-angiotensin system (RAS) exists that is subject to miRNA remodelling. The brain RAS regulates cerebral blood flow, electrolytic balance and is involved in neurotransmitter signalling and cognitive processes. Circulating microRNAs allow interaction between systemic and local RAS in the heart and the brain. Their screening and manipulation may be valuable towards understanding pathophysiology and development of treatments for various systemic and central nervous system diseases. |
| Databáze: | OpenAIRE |
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