Potential virulence determinants in terminal regions of variola smallpox virus genome
| Autor: | Thomas E. Yuran, Li-ing Liu, Joseph J. Esposito, Janice C. Knight, Brian W. J. Mahy, J. Craig Venter, Theresa R. Utterback, Jin Qi, Robert F. Massung, Vladimir N. Loparev, Joseph M. Parsons, Anthony R. Kerlavage, Lisa Aubin, Nickolay A. Selivanov, Kathleen F. Cavallaro |
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| Rok vydání: | 1993 |
| Předmět: |
viruses
Molecular Sequence Data Restriction Mapping Vaccinia virus Genome Viral Virus chemistry.chemical_compound Viral Proteins Sequence Homology Nucleic Acid Animals Humans Poxviridae Orthopoxvirus Smallpox virus Smallpox vaccine Multidisciplinary biology Sequence Homology Amino Acid Virulence Variola virus biology.organism_classification Virology chemistry Chordopoxvirinae DNA Viral Vaccinia |
| Zdroj: | Nature. 366(6457) |
| ISSN: | 0028-0836 |
| Popis: | SMALLPOX eradication culminated the most successful antimicrobial campaign in medical history1. To characterize further the linear double-stranded DNA genome of the aetiological agent of smallpox, we have determined the entire nucleotide sequence of the highly virulent variola major virus, strain Bangladesh-1975 (VAR-BSH; 186,102 base pairs, 33.7% G + C; Genbank accession number, L22579). Here we highlight features of the molecule and focus on a few of the 187 putative proteins that probably contribute to pathogenicity and virus host-range properties. One hundred and fifty proteins were markedly similar to those of vaccinia virus (smallpox vaccine), for which a complete sequence has been reported2,3 for strain Copenhagen (VAC-CPN; 191,636 base pairs, 33.3% G + C). The remaining 37 proteins reflected variola-specific sequences or open reading frame divergences for variant proteins, which are often truncated or elongated compared with their vaccinia counterparts. |
| Databáze: | OpenAIRE |
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