Lymphocyte migration patterns in autoimmune MRL-lpr/lpr mice: relationship to age, disease manifestations and lymphocyte homing receptor expression
| Autor: | Leslie Schrieber, Sharon A. Paull, K. E. Hopper, Nicholas Manolios, Ann K. Guiffre, M. G. Cohen |
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| Rok vydání: | 1989 |
| Předmět: |
Pathology
medicine.medical_specialty medicine.drug_class Lymphocyte Immunology Receptors Lymphocyte Homing Disease urologic and male genital diseases Monoclonal antibody Autoimmune Diseases Histones Mice immune system diseases Cell Movement medicine Immunology and Allergy Animals Lupus Erythematosus Systemic Lymphocytes skin and connective tissue diseases Lymphocyte homing receptor Lymph node Autoantibodies biology business.industry Age Factors Mice Mutant Strains medicine.anatomical_structure biology.protein Cba mice Lymph Nodes Antibody business Abnormal Lymphocyte |
| Zdroj: | Autoimmunity. 3(1) |
| ISSN: | 0891-6934 |
| Popis: | We have previously reported that lymphoid cells from systemic lupus erythematosus (SLE) mice with established disease migrate aberrantly. This study evaluates the abnormal lymphocyte migration patterns found in MRL-lpr/lpr (MRL/l) mice in relation to age, disease manifestations and the expression of lymphocyte homing receptors. 51chromium-labelled lymph node cells from MRL/l and from normal histocompatible CBA mice of different ages were injected i.v. into age and sex-matched CBA recipients. Diminished lymph node and increased hepatic uptake of MRL/l compared to CBA cells was evident as early as 6 weeks of age. Abnormalities in lymphocyte migration antedated the appearance of elevated antihistone antibody (AHA) levels but not the development of lymphadenopathy. Using the monoclonal antibody MEL-14, no differences in the expression of lymphocyte homing receptors between MRL/l and CBA lymph node cells were found at any age. Thus abnormalities in lymphocyte migration in MRL/l mice appear as early as six weeks and are not related to changes in homing receptor expression. |
| Databáze: | OpenAIRE |
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