Synthesis and Investigations of Building Blocks with Dibenzo[b,f] Oxepine for Use in Photopharmacology
| Autor: | Marta Borecka, Hanna Krawczyk, Piotr Tobiasz, Filip Borys |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Light
QH301-705.5 Photochemistry Stereochemistry azo-dibenzo[b f]oxepine derivatives Catalysis photoisomerisation Inorganic Chemistry Isomerism Biology (General) Physical and Theoretical Chemistry tubulin inhibitor QD1-999 Molecular Biology Spectroscopy Molecular Structure Chemistry Communication Organic Chemistry General Medicine Computer Science Applications Theoretical methods Isomerization |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 22, Iss 11033, p 11033 (2021) |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms222011033 |
| Popis: | The synthesis of photoswitchable azo-dibenzo[b,f]oxepine derivatives and microtubule inhibitors were described. Subsequently, we examined the reaction of methoxy derivative 3-nitrodibenzo[b,f]oxepine with different aldehydes and in the presence of BF3·OEt2 as a catalyst. Our study provided a very concise method for the construction of the azo-dibenzo[b,f]oxepine skeleton. The analysis of products was run using experimental and theoretical methods. Next, we evaluated the E/Z isomerization of azo-dibenzo[b,f]oxepine derivatives, which could be photochemically controlled using visible-wavelength light. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|