The Relationship between Dioxin Congeners in the Breast Milk of Vietnamese Women and Sister Chromatid Exchange
| Autor: | Kenji Tawara, Hiroaki Horikawa, Muneko Nishijo, Dang Duc Nhu, Le Thi Hong Thom, Rie Okamoto, Yuko Sato, Hideaki Nakagawa, Nguyen Ngoc Hung, Phung Tri Dung, Teruhiko Kido, Hiroyuki Suzuki |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Adult
medicine.medical_specialty Polychlorinated Dibenzodioxins Polychlorinated dibenzodioxins furans Sister chromatid exchange Breast milk Catalysis Article Inorganic Chemistry Toxicology lcsh:Chemistry chemistry.chemical_compound Equivalent Internal medicine dioxins medicine Humans Physical and Theoretical Chemistry Molecular Biology Biological sciences lcsh:QH301-705.5 Spectroscopy Milk Human Organic Chemistry General Medicine HEXA congener Teratology Computer Science Applications Endocrinology Congener Teratogens chemistry Vietnam lcsh:Biology (General) lcsh:QD1-999 sister chromatid exchange Regression Analysis Environmental Pollutants Female |
| Zdroj: | International Journal of Molecular Sciences, Vol 15, Iss 5, Pp 7485-7499 (2014) International Journal of Molecular Sciences Volume 15 Issue 5 Pages 7485-7499 |
| ISSN: | 1422-0067 |
| Popis: | The aim of this study was to clarify the relationship between dioxin concentrations in breast milk and the sister chromatid exchange (SCE) frequency in women from herbicide-sprayed and non sprayed areas. Blood samples were taken from 21 women with high TCDD (tetrachlorodibenzo-p-dioxin) levels from sprayed areas, 23 women with moderate TCDD levels from sprayed areas, and 19 women from non sprayed areas to determine their SCE frequency. The SCE frequencies for the high and moderate TCDD groups from the sprayed area and for the non sprayed area group were 2.40, 2.19, and 1.48 per cell, respectively. Multiple regression analysis showed that the standardized β values for 1,2,3,6,7,8-hexaCDD (β = 0.60), 1,2,3,4,6,7,8-heptaCDD (β = 0.64), and octaCDD (β = 0.65) were higher than those for TCDD (β = 0.34) and 1,2,3,7,8-pentaCDD (β = 0.42). The adjusted R2 value for polyCDDs (R2 = 0.38) was higher than that for polyCDD toxic equivalents (TEQ (toxic equivalents) R2 = 0.23). This study therefore shows that levels of hexa-, hepta-, and octaCDD, which were previously regarded as being less toxic than TCDD, are closely related to SCE frequency and that the level of dioxin (pg/g lipid) is potentially more useful as an indicator than TEQ value for explaining SCE frequency. |
| Databáze: | OpenAIRE |
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