Effect of bromocriptine on the control of plasma aldosterone diurnal variation in normal supine man
| Autor: | Carmelo Fersini, B.L. Fabbri, R. Pansini, Angelo Margutti, E.C. degli Uberti |
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| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Supine position Hydrocortisone Endocrinology Diabetes and Metabolism Posture Plasma renin activity chemistry.chemical_compound Endocrinology Adrenocorticotropic Hormone Internal medicine Renin medicine Humans Circadian rhythm Aldosterone Bromocriptine business.industry Diurnal temperature variation Prolactin bromocriptine aldosterone Circadian Rhythm chemistry business hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Scopus-Elsevier |
| Popis: | In order to investigate the role of prolactin in the control of the circadian rhythm of plasma aldosterone (PA), plasma renin activity (PRA), cortisol (PC), aldosterone and prolactin (PRL) levels were determined in samples at 4-hour intervals from 5 normal supine men over a period of 24 h under basal conditions and subsequently over a period of 24 h during suppression of prolactin release by bromocriptine (CB-154). After suppression of prolactin, statistically signific1nt circadian rhythms in PC and PA have been detected with a moderate decrease of PA concentration, while the PC level remained unalterated. PRA rhythmicity persisted with a significant shift of acrophase and remarkable reduction of plasma levels. Moreover, during CB administration a significant correlation was obtained between PA and PC, while no correlation was detected between PA and PRA. These data are consistent with the following concepts: (a) the prolactin does not play a significant role in the regulation of circadian rhythm and concentration of plasma aldosterone in normal supine men, and (b) bromocriptine induces a remarkable reduction of PRA and a variable decrease in plasma aldosterone, but it does not influence the secretion of cortisol in normal subjects. |
| Databáze: | OpenAIRE |
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