| Autor: |
Ana María Stella, S. Chinarro, Alcira M. Del C. Batlle, Susana G. Afonso, Rafael Enríquez de Salamanca |
| Rok vydání: |
1986 |
| Předmět: |
|
| Zdroj: |
International Journal of Biochemistry. 18:143-147 |
| ISSN: |
0020-711X |
| DOI: |
10.1016/0020-711x(86)90146-1 |
| Popis: |
1. 1. The effects of light and porphyrins on the activity of red cell uroporphyrinogen decarboxylase were studied. 2. 2. Photoinactivation of uroporphyrinogen decarboxylase was dependent on uroporphyrin concentration, irradiation time and temperature. Using 40 W/m 2 of UV light intensity, 40–45% decreased activity was produced with 200 μM uroporphyrin I, at 37°C and after 2 hr of illumination. 3. 3. It has been demonstrated that porphyrins photoinactivate uroporphyrinogen decarboxylase and a mechanism for this action in relation to skin lesions is proposed. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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