Plasmid-Borne Multiple Drug Resistance in Vibrio cholerae Serogroup O1, Biotype El Tor: Evidence for a Point-Source Outbreak in Bangladesh
| Autor: | Bernard Rowe, E. J. Threlfall, Roger I. Glass, John V. Lee, Abdul Alim, M. I. Huq, M. R. Khan, R. J. Gross |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Flora
medicine.disease_cause El Tor Disease Outbreaks Microbiology Plasmid Cholera medicine Humans Immunology and Allergy Bacteriophage Typing Vibrio cholerae Bangladesh biology Strain (chemistry) Outbreak Drug Resistance Microbial medicine.disease biology.organism_classification Virology Anti-Bacterial Agents Multiple drug resistance Infectious Diseases Plasmids |
| Zdroj: | Journal of Infectious Diseases. 147:204-209 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/147.2.204 |
| Popis: | In 1979, an outbreak of plasmid-borne, multiply drug-resistant Vibrio cholerae serogroup O1 biotype El Tor (V. cholerae O1) occurred in the Matlab area of Bangladesh. The outbreak could have resulted from the introduction into the area of a single resistant strain or from multiple conjugations of drug-sensitive V. cholerae O1 with C plasmids in other environmental flora. Resistant strains were phage typed to determine their relatedness, and plasmid studies were conducted to determine the frequency of C plasmids in nonvibrio flora of family contacts of cholera patients. Forty-one (85%) of 48 resistant strains of V. cholerae O1 examined belonged to two closely related phage types new to the area, whereas 59 drug-sensitive strains from the same period were primarily of two different phage types. Group C plasmids were in nonvibrio strains from five of 36 family contacts of patients with drug-resistant cholera but none of 82 family contacts of patients with sensitive cholera. This outbreak most likely began from the introduction into the area of a single, multiply drug-resistant strain of V. cholerae O1. C plasmids detected in the nonvibrio flora of family contacts probably came from the resistant strain of V. cholerae O1. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|