Ectopic fat storage in the pancreas, liver, and abdominal fat depots: impact on β-cell function in individuals with impaired glucose metabolism
| Autor: | D. H. van Raalte, Petra J. W. Pouwels, Michaela Diamant, Ellen E. Blaak, Gijs H. Goossens, N.J. van der Zijl, Marcel H.A. Muskiet, C.C.M. Moors |
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| Přispěvatelé: | Humane Biologie, RS: NUTRIM - R1 - Metabolic Syndrome, Internal medicine, Physics and medical technology, EMGO - Lifestyle, overweight and diabetes, ICaR - Ischemia and repair |
| Rok vydání: | 2010 |
| Předmět: |
Blood Glucose
Male endocrine system diseases Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry Adipose tissue LIPOTOXICITY Biochemistry Body Mass Index Impaired glucose tolerance Fats Endocrinology Insulin-Secreting Cells MAGNETIC-RESONANCE Fasting Glucose clamp technique Middle Aged Magnetic Resonance Imaging ADIPOSE-TISSUE Liver OBESITY Female Hyperglycemic agent hormones hormone substitutes and hormone antagonists medicine.medical_specialty Abdominal Fat Subcutaneous Fat Context (language use) DEPENDENT DIABETES-MELLITUS INSULIN-SECRETION Prediabetic State Diabetes mellitus Internal medicine Glucose Intolerance medicine Humans Pancreas Aged business.industry Insulin Biochemistry (medical) nutritional and metabolic diseases Overweight ACIDS medicine.disease Impaired fasting glucose DYSFUNCTION Pancreatic Function Tests Diabetes Mellitus Type 2 Glucose Clamp Technique Insulin Resistance business RESISTANCE |
| Zdroj: | Journal of Clinical Endocrinology & Metabolism, 96(2), 459-467. Oxford University Press van der Zijl, N J, Goossens, G H, Moors, C C M, van Raalte, D H, Muskiet, M H A, Pouwels, P J W, Blaak, E E & Diamant, M 2011, ' Ectopic fat storage in the pancreas, liver, and abdominal fat depots: impact on beta-cell function in individuals with impaired glucose metabolism ', Journal of Clinical Endocrinology and Metabolism, vol. 96, no. 2, pp. 459-467 . https://doi.org/10.1210/jc.2010-1722 Journal of Clinical Endocrinology and Metabolism, 96(2), 459-467. The Endocrine Society |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jc.2010-1722 |
| Popis: | Context: Pancreatic fat content (PFC) may have deleterious effects on β-cell function. Objective: We hypothesized that ectopic fat deposition, in particular pancreatic fat accumulation, is related to β-cell dysfunction in individuals with impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT). Design, Setting and Participants: This was a cross-sectional study in 64 age- and body mass index-matched individuals, with normal glucose tolerance (NGT; n = 16, 60% males), IFG (n = 29, 52% males), or IFG/IGT (n = 19, 63% males) was conducted. Intervention and Main Outcome Measures: Participants underwent the following: 1) a combined hyperinsulinemic-euglycemic and hyperglycemic clamp, with subsequent arginine stimulation to quantify insulin sensitivity and β-cell function; 2) proton-magnetic resonance spectroscopy to assess PFC and liver fat content (LFC); and 3) magnetic resonance imaging to quantify visceral (VAT) and sc (SAT) adipose tissue. The disposition index (DI; insulin sensitivity adjusted β-cell function) was assessed. Results: IFG and IFG/IGT were more insulin resistant (P < 0.001) compared with NGT. Individuals with IFG/IGT had the lowest values of glucose- and arginine-stimulated C-peptide secretion (both P < 0.03) and DI (P < 0.001), relative to IFG and NGT. PFC and LFC gradually increased between NGT, IFG, and IFG/IGT (P = 0.02 and P = 0.01, respectively), whereas VAT and SAT were similar between groups. No direct associations were found between PFC, LFC, VAT, and SAT and C-peptide secretion. The DI was inversely correlated with PFC, LFC, and VAT (all P < 0.05). Conclusions: PFC was increased in individuals with IFG and/or IGT, without a direct relation with β-cell function. |
| Databáze: | OpenAIRE |
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