Immunoglobulin Classification Using the Colored Antibody Graph
| Autor: | Stefano Bonissone, Pavel A. Pevzner |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Population Immunoglobulins Somatic hypermutation Computational biology Biology De Bruijn graph Mice 03 medical and health sciences symbols.namesake Antibody Repertoire Genetics Animals Humans education Somatic recombination Molecular Biology B-Lymphocytes education.field_of_study Repertoire V(D)J recombination Computational Biology V(D)J Recombination Computational Mathematics 030104 developmental biology Computational Theory and Mathematics Modeling and Simulation symbols Graph (abstract data type) RECOMB 2015: Part 2 of 2Guest Editor: Teresa PrzytyckaResearch Articles Algorithms |
| Zdroj: | Journal of Computational Biology. 23:483-494 |
| ISSN: | 1557-8666 1066-5277 |
| DOI: | 10.1089/cmb.2016.0010 |
| Popis: | The somatic recombination of V, D, and J gene segments in B-cells introduces a great deal of diversity, and divergence from reference segments. Many recent studies of antibodies focus on the population of antibody transcripts that show which V, D, and J gene segments have been favored for a particular antigen, a repertoire. To properly describe the antibody repertoire, each antibody must be labeled by its constituting V, D, and J gene segment, a task made difficult by somatic recombination and hypermutation events. While previous approaches to repertoire analysis were based on sequential alignments, we describe a new de Bruijn graph–based algorithm to perform VDJ labeling and benchmark its performance. |
| Databáze: | OpenAIRE |
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