Hypoxia-inducible-factor-1 in trauma and critical care
| Autor: | Elina R. Paul, Dorian A. Bogdanovski, Stefanie A. Pilip, Anastasia K. Bogdanovski, Garrett B. Jordan, Luca Antonioli, Balázs Csóka, Zoltán Németh, Louis T. DiFazio |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Hypoxia-Inducible Factor 1 Pathology medicine.medical_specialty Critical Care Acute Lung Injury Ischemia Inflammation Critical Care and Intensive Care Medicine Bioinformatics Sepsis 03 medical and health sciences 0302 clinical medicine Brain Injuries Traumatic medicine Humans Clinical significance Hypoxia HIF-1 business.industry Hypoxia (medical) medicine.disease Up-Regulation 030104 developmental biology Liver Wounds and Injuries medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Critical Care. 42:207-212 |
| ISSN: | 0883-9441 |
| DOI: | 10.1016/j.jcrc.2017.07.029 |
| Popis: | HIF-1 is a ubiquitous signaling molecule constantly expressed by the body, but is degraded during normoxic conditions. In hypoxic conditions, it persists and is active. Hypoxia is often associated with trauma due to interrupted blood flow, inflammation or other reasons, causing HIF-1 to be active in signaling and recovery. In this review, the function of HIF-1 is examined, as well as its clinical significance with regard to trauma and critical care. Using this information, we then identify potential points of treatment and intervention. |
| Databáze: | OpenAIRE |
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