Congenital Varicella-Zoster Virus Infection and Barrett's Esophagus
| Autor: | Carol J. Baker, Kenneth K. Lee, Anne A. Gershon, Xilla T. Ussery, Paula W. Annunziato, Octavian Lungu, Saul Silverstein, Claire Langston, Barbara S. Reid |
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| Rok vydání: | 1998 |
| Předmět: |
Pathology
medicine.medical_specialty viruses Congenital Varicella Syndrome Biology medicine.disease_cause Herpes Zoster Herpesviridae Immediate-Early Proteins Barrett Esophagus Esophagus Viral Envelope Proteins Pregnancy medicine Humans Immunology and Allergy Pregnancy Complications Infectious integumentary system Esophageal disease Infant Newborn Varicella zoster virus Infant virus diseases Intestinal metaplasia biochemical phenomena metabolism and nutrition medicine.disease eye diseases Virus Latency Esophageal Tissue Infectious Diseases medicine.anatomical_structure Barrett's esophagus DNA Viral Trans-Activators Female |
| Zdroj: | Journal of Infectious Diseases. 178:539-543 |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | Congenital varicella syndrome is a rare complication of varicella-zoster virus (VZV) infection during pregnancy. An infant was exposed to VZV at 18.5 weeks of gestation and had eye and skin abnormalities at birth and persistent feeding difficulties, prompting esophageal biopsies at 12 days and 20 and 20.5 months of age. Esophageal tissues demonstrated specialized intestinal metaplasia (Barrett's esophagus). VZV DNA (in situ hybridization) and proteins (immunohistochemistry and polymerase chain reaction) were found in esophageal epithelial cells adjacent to the Barrett's lesion. Immediate-early 63 protein (IE63) of VZV was demonstrated in the day 12 specimen, and IE62 and the late VZV glycoprotein E (gE) were found in the 20-month specimen. Clinical and endoscopic improvement followed fundoplication and acyclovir therapy, but VZV DNA and IE62 persisted in esophageal tissue. These findings associate VZV with specialized intestinal metaplasia within the esophagus and suggest a novel site for either latent or active VZV infection. |
| Databáze: | OpenAIRE |
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