Unconventional antigen-presenting cells in the induction of peripheral CD8+ T cell tolerance
| Autor: | Erika D. Reynoso, Shannon J. Turley |
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| Rok vydání: | 2009 |
| Předmět: |
Cell type
Liver cytology T cell Immunology Bone Marrow Cells CD8-Positive T-Lymphocytes Biology Antigen In vivo medicine Animals Humans Immunology and Allergy Cytotoxic T cell Antigen-presenting cell Skin Dendritic Cells Cell Biology Cell biology Self Tolerance medicine.anatomical_structure Liver Organ Specificity Lymph Nodes CD8 |
| Zdroj: | Journal of Leukocyte Biology. 86:795-801 |
| ISSN: | 1938-3673 0741-5400 |
| DOI: | 10.1189/jlb.0509362 |
| Popis: | This review highlights the role of nonhematopoietic cells in the induction and maintenance of peripheral CD8+ T cell tolerance. Bone marrow-derived APCs are considered the predominant cell type involved in the induction and maintenance of T cell tolerance in vivo. In the periphery, cross-presentation of self-antigens by DCs, in particular, CD8α+ DCs, has been the most discussed mechanism underlying the induction of CD8+ T cell tolerance against self. However, nonhematopoietic APCs in the liver, skin, parenchymal tissues, and lymph nodes can also present self- and exogenous antigens to CD8+ T cells under steady-state conditions. Although far surpassed by their DC counterparts in their ability to stimulate T cell responses, these unconventional APCs have been shown to play a role in the induction, maintenance, and regulation of peripheral CD8+ T cell tolerance by a multitude of mechanisms. In this review, we will discuss the different nonhematopoietic cells that have been shown to present tissue-specific or exogenous antigens to naïve CD8+ T cells, thereby contributing to the regulation of T cell responses in the periphery. |
| Databáze: | OpenAIRE |
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