6,7-Dihydro-5-[[(cis-2-hydroxy-trans-3-Phenoxycylopentyl)amino]methyl]-2-methylbenzo[b]thiophen-4(5H)-one: a novel .alpha.1-adrenergic receptor antagonist and renal vasodilator
| Autor: | Broersma Rj, LeTourneau Me, P. J. Shea, M. B. Zimmerman, Jeffrey P. Whitten, N. L. Wiech, McCarthy, D. L. Trepanier, John C. Huffman, P. E. Wiedeman |
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| Rok vydání: | 1985 |
| Předmět: |
Male
Ketone Chemical Phenomena Stereochemistry Natriuresis Vasodilation Thiophenes α1 adrenergic receptor Renal Circulation Dogs Rats Inbred SHR Drug Discovery Animals Adrenergic alpha-Antagonists Alpha-1 adrenergic receptor chemistry.chemical_classification Bicyclic molecule Chemistry Antagonist Stereoisomerism Biological activity Prazosin Receptors Adrenergic alpha Rats Hypertension Molecular Medicine Rabbits |
| Zdroj: | Journal of Medicinal Chemistry. 28:1142-1145 |
| ISSN: | 1520-4804 0022-2623 |
| DOI: | 10.1021/jm00147a003 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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