Efficacy of Mesoglycan in Pain Control after Excisional Hemorrhoidectomy. A Pilot Comparative Prospective Multicenter Study
| Autor: | Alberto Realis Luc, Massimiliano Mistrangelo, Valentina Testa, Elettra Ugliono, G. Clerico, Mario Trompetto, Gaetano Gallo, Ivan Lanati, Ivano Lazzari, Roberto Perinotti, Paolo Tonello, Roberto Passera, Emilia De Luca, Mauro Pozzo |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Article Subject medicine.medical_treatment Mucocutaneous zone 030230 surgery 03 medical and health sciences 0302 clinical medicine Edema Antithrombotic medicine lcsh:RC799-869 Hepatology medicine.diagnostic_test business.industry Incidence (epidemiology) Gastroenterology Diathermy Rectal examination medicine.disease Thrombosis Surgery Clinical Study lcsh:Diseases of the digestive system. Gastroenterology 030211 gastroenterology & hepatology Observational study medicine.symptom business |
| Zdroj: | Gastroenterology Research and Practice Gastroenterology Research and Practice, Vol 2018 (2018) |
| Popis: | Introduction. Various pain management strategies for patients undergoing open excisional hemorrhoidectomy have been proposed, yet postoperative pain remains a frequent complaint. Objective. To determine whether mesoglycan (30 mg two vials i.m. once/day for the first 5 days postoperative, followed by 50 mg 1 oral tablet twice/day for 30 days) would reduce the edema of the mucocutaneous bridges and thus improve postoperative pain symptoms. Patients and Methods. For this prospective observational multicenter study, 101 patients undergoing excisional diathermy hemorrhoidectomy for III-IV degree hemorrhoidal disease were enrolled at 5 colorectal referral centers. Patients were assigned to receive either mesoglycan (study group SG) or a recommended oral dose of ketorolac tromethamine of 10 mg every 4–6 hours, not exceeding 40 mg per day and not exceeding 5 postoperative days according to the indications for short-term management of moderate/severe acute postoperative pain, plus stool softeners (control group CG). Results. Postoperative thrombosis (SG 1/48 versus CG 5/45) (p<0.001) and pain after rectal examination (p<0.001) were significantly reduced at 7–10 days after surgery in the mesoglycan-treated group, permitting a faster return to work (p<0.001); however, in the same group, the incidence of postoperative bleeding, considered relevant when needing a readmission or an unexpected outpatient visit, was higher, possibly owing to the drug’s antithrombotic properties. Conclusions. The administration of mesoglycan after an open diathermy excisional hemorrhoidectomy can reduce postoperative thrombosis and pain at 7–10 days after surgery, permitting a faster return to normal activities. |
| Databáze: | OpenAIRE |
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