Outcomes of intra-arterial thrombolysis for acute limb ischemia
Autor: | M. Cleanthis, Grace Timmons, Colin Nice, S.J. Amonkar, Hamdy Ashour, Vishwanath Bhattacharya, Ahmed Mudawi |
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Rok vydání: | 2008 |
Předmět: |
Adult
Male medicine.medical_specialty Time Factors medicine.medical_treatment Limb salvage Ischemia Less invasive Fibrinolytic Agents Medicine Initial treatment Humans Infusions Intra-Arterial Thrombolytic Therapy Aged Retrospective Studies Aged 80 and over business.industry Anticoagulants Extremities Thrombolysis Middle Aged medicine.disease Limb Salvage Limb ischemia Alternative treatment Surgery body regions Intra arterial thrombolysis Radiography Treatment Outcome Tissue Plasminogen Activator Acute Disease Female Cardiology and Cardiovascular Medicine business Vascular Surgical Procedures Follow-Up Studies |
Zdroj: | Angiology. 58(6) |
ISSN: | 0003-3197 |
Popis: | Intra-arterial thrombolysis is an alternative treatment to surgery for acute limb ischemia. We report our own experiences by retrospectively assessing initial and long-term outcomes using this strategy. Patients (n = 48; 50 events) underwent thrombolysis according to our protocol (64.6% male, median age 68.5 years). Using thrombolysis as an initial treatment strategy, overall limb survival on index admission was 84%. Of this group who had successful limb salvage, 76% was attributable to thrombolysis alone, and 24% had limb salvage attributable to subsequent surgery after failed thrombolysis or anticoagulation. Significant complications occurred in 8% of cases, and no deaths were attributed to thrombolysis. Patients alive at 6 and 24 months after index admission who had limb salvage attributable to thrombolysis alone had limb survival rates of 89% and 82%, respectively. The majority of these patients had not required subsequent secondary procedures to maintain limb survival. Thrombolysis is an acceptable and less invasive treatment of acute limb ischemia, with many patients not needing subsequent surgery. |
Databáze: | OpenAIRE |
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