Driving Forces of Liquid–Liquid Phase Separation in Biological Systems
| Autor: | Luisa A. Ferreira, Vladimir N. Uversky, Boris Y. Zaslavsky |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
liquid–liquid phase separation
Materials science Cells lcsh:QR1-502 interfacial tension Biochemistry Phase Transition lcsh:Microbiology Surface tension 03 medical and health sciences 0302 clinical medicine solvent features of water Liquid liquid Molecular Biology 030304 developmental biology chemistry.chemical_classification 0303 health sciences Aqueous solution Aqueous two-phase system Proteins Water Polymer aqueous two-phase system phase-forming polymer Solvent Editorial chemistry Chemical engineering Scientific method Solvents 030217 neurology & neurosurgery Macromolecule |
| Zdroj: | Biomolecules, Vol 9, Iss 9, p 473 (2019) Biomolecules |
| Popis: | Analysis of liquid–liquid phase separation in biological systems shows that this process is similar to the phase separation observed in aqueous two-phase systems formed by nonionic polymers, proteins, and polysaccharides. The emergence of interfacial tension is a necessary condition of phase separation. The situation in this regard is similar to that of phase separation in mixtures of partially miscible solvents. It is suggested that the evaluation of the effects of biological macromolecules on the solvent properties of aqueous media and the measurement of the interfacial tension as a function of these solvent properties may be more productive for gaining insights into the mechanism of liquid–liquid phase separation than the study of structural details of proteins and RNAs engaged in the process. |
| Databáze: | OpenAIRE |
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