The Impact of Ethnicity and Country of Birth on Inflammatory Bowel Disease Phenotype: a Prospective Cohort Study
| Autor: | Spekhorst, L.M., Severs, M., Boer, N.K.H. de, Festen, E.A.M., Fidder, H.H., Hoentjen, F., Imhann, F., Jong, D.J. de, Meulen-de Jong, A.E. van der, Pierik, M.J., Woude, C.J. van der, Dijkstra, G., Ponsioen, C.Y., Lowenberg, M., Oldenburg, B., Weersma, R.K., Parelsnoer Inst, Dutch Initiative Crohn Colitis |
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| Přispěvatelé: | Gastroenterology and Hepatology, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Cardio Thoracale Chirurgie, Interne Geneeskunde, MUMC+: MA Maag Darm Lever (9), RS: NUTRIM - R2 - Liver and digestive health, RS: NUTRIM - R2 - Gut-liver homeostasis, Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Translational Immunology Groningen (TRIGR), Groningen Institute for Organ Transplantation (GIOT), AII - Inflammatory diseases, AGEM - Digestive immunity, Gastroenterology and hepatology, Gastroenterology & Hepatology |
| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Pediatrics ENVIRONMENTAL RISK-FACTORS Anal Canal Constriction Pathologic Disease Inflammatory bowel disease 0302 clinical medicine Crohn Disease Residence Characteristics Epidemiology EPIDEMIOLOGY Prospective Studies Age of Onset Prospective cohort study NON-HISPANIC WHITES Digestive System Surgical Procedures POPULATION Netherlands education.field_of_study Crohn's disease Gastroenterology General Medicine Middle Aged Ulcerative colitis CROHNS-DISEASE Europe ULCERATIVE-COLITIS ethnicity Female 030211 gastroenterology & hepatology Inflammatory diseases Radboud Institute for Molecular Life Sciences [Radboudumc 5] Adult medicine.medical_specialty PACIFIC MIGRATION phenotype Population UNITED-STATES Other Research Radboud Institute for Molecular Life Sciences [Radboudumc 0] White People 03 medical and health sciences All institutes and research themes of the Radboud University Medical Center Intestinal Fistula medicine Humans education Aged ulcerative colitis business.industry medicine.disease Non-Hispanic whites digestive system diseases 030104 developmental biology Colitis Ulcerative SOUTH ASIANS business |
| Zdroj: | Journal of Crohn's and Colitis, 11, 1463-1470 Journal of Crohn's and Colitis, 11(12), 1463-1470 Spekhorst, L M, Severs, M, de Boer, N K H, Festen, E A M, Fidder, H H, Hoentjen, F, Imhann, F, de Jong, D J, van der Meulen-de Jong, A E, Pierik, M J, van der Woude, C J, Dijkstra, G, Ponsioen, C Y, Löwenberg, M, Oldenburg, B, Weersma, R K & Parelsnoer Institute and the Dutch Initiative on Crohn and Colitis 2017, ' The Impact of Ethnicity and Country of Birth on Inflammatory Bowel Disease Phenotype : a Prospective Cohort Study ', Journal of Crohn's & colitis, vol. 11, no. 12, pp. 1463-1470 . https://doi.org/10.1093/ecco-jcc/jjx098 Journal of Crohn s & colitis, 11(12), 1463-1470. Elsevier Journal of Crohn's & Colitis, 11(12), 1463-1470. Oxford University Press Journal of Crohn's and Colitis, 11(12), 1463-1470. Oxford University Press Journal of Crohn's & colitis, 11(12), 1463-1470. Elsevier Journal of Crohn's and Colitis, 11, 12, pp. 1463-1470 |
| ISSN: | 1873-9946 |
| DOI: | 10.1093/ecco-jcc/jjx098 |
| Popis: | Background and Aims: The number of patients with inflammatory bowel disease [IBD], of non-Caucasian descent in Western Europe, is increasing. We aimed to explore the impact of ethnicity and country of birth on IBD phenotype.Methods: IBD patients treated in the eight University Medical Centers in The Netherlands [Dutch IBD Biobank] were divided into two groups according to their ethnicity: 1] Caucasian patients of Western and Central European descent [CEU]; and 2] patients of non-Caucasian descent [non-CEU]. The non-CEU group was subdivided according to country of birth, into: born in The Netherlands or Western Europe [non-CEU European born]; or born outside Western-Europe who migrated to The Netherlands [non-CEU non-European born]. Both comparisons were analysed for phenotype differences [by chi-square test].Results: The Dutch IBD Biobank included 2921 CEU patients and 233 non-CEU patients. Non-CEU Crohn's disease [CD] patients more often had upper gastro-intestinal disease [16% vs 8%, p = 0.001] and anal stenosis [10% vs 4%, p = 0.002] than CEU CD patients. The use of anti-tumour necrosis factor [TNF] agents and immunomodulators was higher in non-CEU IBD patients than in CEU IBD patients [45% vs 38%, p = 0.042] and [77% vs 66%, p = 0.001], respectively. Non-CEU IBD patients born in Europe [n = 116] were diagnosed at a lower age than non-CEU IBD patients born outside Europe [n = 115] [at 22.7 vs 28.9 years old, p < 0.001].Conclusion: Non-Caucasians had more severe disease behaviour than Caucasians. Non-CEU patients born in Europe were diagnosed at a lower age with IBD than those born outside Europe who migrated to The Netherlands. |
| Databáze: | OpenAIRE |
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