Rheumatoid arthritis‐associated antibodies in healthy first‐degree relatives of RA patients

Autor: David Vega‐Morales, Lorena Pérez‐Barbosa, Luis Francisco Vega‐Sevilla, Jorge Antonio Esquivel‐Valerio, Luis Eduardo Ramírez‐Monterrubio, Karina I Gonzalez‐Torres, Ana Sofía Leal‐Bramasco, Cesar V Elizondo‐Solis, Andres Mendiola‐Jimenez, Mario Alberto Garza‐Elizondo, Dionicio Ángel Galarza‐Delgado
Rok vydání: 2022
Předmět:
Zdroj: International Journal of Immunogenetics. 50:19-23
ISSN: 1744-313X
1744-3121
DOI: 10.1111/iji.12608
Popis: Rheumatoid arthritis (RA) affects approximately 1.5% of the population worldwide and 0.5-3.3% of the Mexican population. The presence of rheumatoid factor (RF), anti-citrullinated protein antibodies (ACPA) and anti-carbamylated protein (anti-CarP) antibodies has been described in populations at risk of RA development, such as first-degree relatives (FDR). Anti-CarP antibodies are present in RA patients (44%), FDR of RA patients (18%) and healthy controls (4.7%). Anti-CarP antibodies have not been described in FDR of the Mexican population. The objective of this study was to determine the prevalence of Rheumatoid Factors (RF) isotypes, ACPA and anti-CarP antibodies isotypes in FDR of RA patients. An observational, cross-sectional study, in an FDR of RA cohort, was performed. We measured IgA, IgG and IgM isotypes of RF, ACPA and anti-CarP antibodies. A total of 144 FDRs from 99 RA patients were enrolled. The prevalence of anti-CarP antibodies was 2.8% for IgA, 4.2% for IgG, whereas IgM was not detected. The serologic association was for RF/ACPA 4.48%, RF/anti-CarP 2.7%, FR 64.5%, ACPA 1.3%, ACPA/anti-CarP 0.69%, anti-CarP 3.4%, and no RF/ACPA/anti-CarP was observed. We found a low prevalence of anti-CarP antibodies in our cohort of FDR of RA patients, but the prevalence of ACPA and RF were higher than other cohorts previously reported.
Databáze: OpenAIRE
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