The assessment of drug safety for the fetus
| Autor: | Eric M. Hecht |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Drug
medicine.medical_specialty Drug-Related Side Effects and Adverse Reactions media_common.quotation_subject Effects medications Pharmaceutical Science Pharmacy Gestational Age Toxicology Risk Assessment Child health law.invention Fetus Randomized controlled trial law Pregnancy Risk Factors medicine Humans Pharmacology (medical) Pharmacokinetics Intensive care medicine Maternal-Fetal Exchange media_common Pharmacology business.industry medicine.disease Toxicokinetics Maternal Exposure Gestation Female business |
| Zdroj: | International journal of clinical pharmacy. 42(6) |
| ISSN: | 2210-7711 |
| Popis: | Long standing concerns regarding the use of medications during pregnancy and their unknown effects on fetal development and child health suggests the need for modified study methods regarding the establishment of drug safety for the fetus. This Current Commentary highlights several pharmacological study method limitations and offers suggestions for the establishment of drug safety for the fetus. For example, extensive phase 1 pharmacology studies are needed to assess the complex pharmacokinetic relationships between mother and fetus in order to determine injurious doses to the fetus throughout pregnancy. In addition, long term randomized clinical trials are needed to assess the effects medications may have on children following exposure during gestation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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