Lymphatic vessel density in vocal cord carcinomas assessed with LYVE-1 receptor expression

Autor: Heikki Joensuu, Ilmo Leivo, Antti Vaheri, Walter J. Koskinen, Petri Bono, Leena-Maija Aaltonen
Rok vydání: 2005
Předmět:
Male
Pathology
Receptor expression
Vesicular Transport Proteins
Vocal Cords
Metastasis
Cohort Studies
0302 clinical medicine
Aged
80 and over
0303 health sciences
Biopsy
Needle
Hematology
Middle Aged
Prognosis
Immunohistochemistry
3. Good health
Gene Expression Regulation
Neoplastic
Survival Rate
medicine.anatomical_structure
Oncology
Cervical lymph nodes
Head and Neck Neoplasms
030220 oncology & carcinogenesis
Carcinoma
Squamous Cell
Female
Adult
medicine.medical_specialty
Cord
Sensitivity and Specificity
Statistics
Nonparametric
03 medical and health sciences
Predictive Value of Tests
medicine
Lymphatic vessel
Carcinoma
Biomarkers
Tumor
Humans
Radiology
Nuclear Medicine and imaging
Laryngeal Neoplasms
030304 developmental biology
Aged
Glycoproteins
Lymphatic Vessels
Neoplasm Staging
Probability
business.industry
Head and neck cancer
medicine.disease
Head and neck squamous-cell carcinoma
Logistic Models
Lymph Nodes
business
Zdroj: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 77(2)
ISSN: 0167-8140
Popis: Background and purpose Early stage vocal cord carcinomas are usually cured by radiation therapy despite the use of portals that exclude the cervical lymph nodes. We investigated whether the lymphatic vessel density (LVD) of vocal cord carcinomas differs from that of other head and neck carcinomas. Patients and methods Deparaffinized tissue from tumors of 60 patients diagnosed with head and neck squamous cell carcinoma (HNSCC) were immunostained for LYVE-1, a novel lymphatic vessel marker. Twenty-two had vocal cord carcinoma. Tumor blood vessel density (BVD) was assessed using immunostaining for CD31. Results Tumor overall LVD, including both intra- and peritumoral lymph vessels, was 10-fold lower than the BVD (5counts/mm 2 vs. 52mm −2 , respectively). A high LVD was associated with a high BVD ( P =.002), but neither was associated with the tumor size. Both tumor LVD and BVD were lower in vocal cord carcinomas than in HNSCCs arising at other sites (median, 0 vs. 7mm −2 , P =.016; and median, 36 vs. 52mm −2 , P =.006, respectively). Only one vocal cord carcinoma was associated with a regional metastasis at the time of the diagnosis. Among the rest of the cases tumor size was a better predictor for the presence of regional metastases than tumor BVD or LVD in a logistic regression model (odds ratio 2.2, 95% CI 1.1–4.5). Conclusion Vocal cord carcinomas have a low lymph vessel density as compared with HNSCCs arising at other sites.
Databáze: OpenAIRE
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