The value of pancreatic stone protein in the prediction of infected neonates
| Autor: | Rong Wu, Jian-Ming Wu, Li Zha, Jinhui Hu, Zhao-Fang Tian |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Enzyme-Linked Immunosorbent Assay Gastroenterology Sepsis Predictive Value of Tests Internal medicine Lithostathine medicine Humans Prospective Studies Prospective cohort study business.industry Infant Newborn Area under the curve Case-control study medicine.disease eye diseases ROC Curve Case-Control Studies Predictive value of tests Pediatrics Perinatology and Child Health Population study Biomarker (medicine) Female Pancreatic stone protein business Biomarkers |
| Zdroj: | Minerva Pediatrics. 69 |
| ISSN: | 2724-5780 2724-5276 |
| Popis: | Background The aim of this study was to determine serum pancreatic stone protein (PSP) levels in the neonates with highly probable or probable sepsis and assess their possible value in predicting infected neonates. Methods This was a prospective study involving 119 neonates who were admitted with suspected sepsis. The study population was divided into two groups, a infected group (N.=40, with highly probable sepsis or probable sepsis) and control group (N.=79, with possible or no sepsis). The blood samples were obtained at 24, 72 and 168 hours after birth. The amount of serum PSP were detected by enzyme linked immunosorbent (ELISA). Results PSP serum concentrations were higher in the infected group comparison to the control group at all time points (all P=0.000). In addition the sequential comparison between the infected group and control group at all of time points was significantly different (F=48.558, P=0.000). ROC area under the curve (AUC) was 0.791 [95% CI: 0.71-0.87; P=0.000] for PSP at 24 hours after birth and 0.790 (95% CI: 0.79-0.88; P=0.000) 72 hours after birth and combination of the two time points (24 and 72 hours), the AUC was 0.819 (95% CI: 0.74-0.90; P=0.000). Conclusions PSP is a valuable biomarker in predicting infected neonates. Combination of PSP at each time point within 72 hours after birth might be better. |
| Databáze: | OpenAIRE |
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