The association between carotid disease, arterial stiffness and diabetic retinopathy in type 2 diabetes: the Fremantle Diabetes Study Phase II
| Autor: | Jocelyn J. Drinkwater, Timothy M. E. Davis, A M Brooks, Wendy A. Davis, Angus W. Turner, B T Davis, Fred K. Chen |
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| Rok vydání: | 2020 |
| Předmět: |
Carotid Artery Diseases
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Type 2 diabetes Pulse Wave Analysis Carotid Intima-Media Thickness 03 medical and health sciences 0302 clinical medicine Endocrinology Vascular Stiffness Risk Factors Internal medicine Diabetes mellitus Internal Medicine medicine Humans 030212 general & internal medicine Pulse wave velocity Macrovascular disease Aged Ultrasonography Aged 80 and over Diabetic Retinopathy medicine.diagnostic_test business.industry Carotid ultrasonography Fundus photography Australia Diabetic retinopathy Middle Aged medicine.disease Cross-Sectional Studies Diabetes Mellitus Type 2 Cardiology Arterial stiffness Female business Diabetic Angiopathies |
| Zdroj: | Diabetic medicine : a journal of the British Diabetic AssociationREFERENCES. 38(4) |
| ISSN: | 1464-5491 |
| Popis: | Aim To determine whether macrovascular disease assessed by carotid ultrasonography and arterial stiffness by pulse wave velocity are independently associated with diabetic retinopathy in type 2 diabetes. Methods A random subgroup of surviving participants with type 2 diabetes from the Fremantle Diabetes Study Phase II were invited to take part in this sub-study in 2018-2019. In addition to standardized questionnaires, a physical examination and fasting biochemical tests, each underwent dilated colour fundus photography, carotid arterial ultrasonography with measurement of the intima-media thickness (IMT) and quantification of the degree of stenosis, and pulse wave analysis calculation of the carotid-femoral pulse wave velocity (cfPWV). The cross-sectional association between arterial disease parameters and diabetic retinopathy was assessed using generalized estimating equation models which enabled both eyes to be included in the analysis. Results Some 270 participants [mean ± sd age 72 ± 9 years, 153 (57%) men and median (IQR) diabetes duration 15 [11-22) years] were included in analysis. Of 524 assessable eyes, 82 (16%) had diabetic retinopathy. In multivariable analysis, significant independent associates of diabetic retinopathy were age at diabetes diagnosis (inversely), HbA1c , insulin treatment and urinary albumin to creatinine ratio (all P ≤ 0.022), as well as cfPWV [odds ratio (OR) 1.13, 95% confidence interval (CI) 1.03, 1.23 per 1 m/s increase; P = 0.008] and common carotid artery (CCA) IMT ≥ 1 mm (OR 2.95, 95% CI 1.21, 7.23; P = 0.018). Conclusions The association between diabetic retinopathy and CCA IMT suggests that carotid disease may share cardiovascular risk factors with diabetic retinopathy. The association between diabetic retinopathy and cfPWV may reflect the consequences of altered intravascular haemodynamics. |
| Databáze: | OpenAIRE |
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