Ecotoxicological biomarkers as investigating tools to evaluate the impact of acrylamide on Theba pisana snails
| Autor: | K.S. El-Gendy, M. A. Radwan, El-Sayed H. Eshra, Amira F. Gad, Awatef E. Khamis |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Health
Toxicology and Mutagenesis Snails Theba pisana 010501 environmental sciences medicine.disease_cause Ecotoxicology 01 natural sciences Lipid peroxidation Lethal Dose 50 chemistry.chemical_compound medicine Environmental Chemistry Animals 0105 earth and related environmental sciences Glutathione Transferase Acrylamide Glutathione Peroxidase biology General Medicine Glutathione biology.organism_classification Catalase Pollution Oxidative Stress Biochemistry chemistry biology.protein Environmental Pollutants Lipid Peroxidation Oxidative stress Genotoxicity Biomarkers |
| Zdroj: | Environmental science and pollution research international. 26(14) |
| ISSN: | 1614-7499 |
| Popis: | Acrylamide (ACR) is a widespread industrial chemical with recognized adverse effects not only to humans but to other organisms in the environment as well. In the present study, the ecotoxicological effects of dietary exposure to sublethal concentration (1/20 LC50) of ACR on the land snail, Theba pisana after 2 weeks of exposure and 1-week recovery with respect to oxidative stress parameters; lipid peroxidation (LPO), reduced glutathione (GSH), catalase (CAT), and glutathione-S-transferase (GST), cytogenetic parameter; deoxyribonucleic acid (DNA) content, as well as immunological parameters; cell death, phagocytosis, lysosomal membrane stability (LMS), lectins, superoxide anion (O2−) generation, phenoloxidase (PO), peroxidase (POD), and hemocyanin (Hc) were examined. The results showed that ACR significantly increased LPO level and the activity of CAT and GST, cell death, and Hc level, whereas a significant decline in DNA and GSH contents, phagocytic activity, LMS, lectins, O2− generation, POD, and PO activities compared to the controls after 2-week exposure was observed. After 1-week recovery, most of the tested parameters in exposed snails were permanent and not reversible to the control levels. This study suggests that the tested multiple parameters of T. pisana species may be used as biomarkers of ACR exposure. Besides, T. pisana snails could be used as a good sentinel organism for ACR exposure in pollution monitoring studies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink