A retrospective, cross-sectional study reveals that women with CRSwNP have more severe disease than men
| Autor: | Atsushi Kato, Robert C. Kern, Lydia Suh, Kathryn E. Hulse, Whitney W. Stevens, Leslie C. Grammer, Margrit Urbanek, James E. Norton, Bruce K. Tan, Anju T. Peters, Kathleen E. Harris, Robert P. Schleimer, Rakesh K. Chandra, Roderick G. Carter, David B. Conley |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
chronic inflammation Chronic rhinosinusitis Cross-sectional study Immunology Severe disease oral steroids Disease 03 medical and health sciences 0302 clinical medicine Internal medicine Immunology and Allergy Medicine Nasal polyps 030223 otorhinolaryngology Asthma Original Research business.industry chronic rhinosinusitis Respiratory disease Aspirin hypersensitivity asthma medicine.disease 3. Good health AERD 030228 respiratory system business |
| Zdroj: | Immunity, Inflammation and Disease |
| ISSN: | 2050-4527 |
| Popis: | Up to 50% of patients with chronic rhinosinusitis (CRS) have comorbid asthma, and we have reported that a subset of CRS patients who have nasal polyps (CRSwNP) have elevated autoantigen-specific antibodies within their nasal polyps (NP). While increases in the prevalence and/or severity of both asthma and autoimmunity in women are well characterized, it is not known whether CRSwNP is more severe or frequent in women than men. We sought to determine whether CRSwNP demonstrated sex-specific differences in frequency and/or severity. Using a retrospectively collected database of tertiary care patients (n = 1393), we evaluated the distribution of sex in patients with CRSwNP with or without comorbid asthma or aspirin hypersensitivity. We further compared the severity of sinus disease between men and women with CRSwNP. Although women comprised 55% of CRS patients without NP (CRSsNP), a significantly smaller proportion of CRSwNP patients were female (38%, P |
| Databáze: | OpenAIRE |
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