Expression of genes encoding centrosomal proteins and the humoral response against these proteins in chronic myeloid leukemia
| Autor: | Michal Smahel, Jana Smahelova, Eva Hamsikova, Kateřina Machová Poláková, Iva Kaštánková, Ruth Tachezy, Karla Zemanova, Hana Klamova |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Male Cancer Research Cell Cycle Proteins Trithorax-group proteins 03 medical and health sciences Basal (phylogenetics) Young Adult 0302 clinical medicine Leukemia Myelogenous Chronic BCR-ABL Positive medicine Humans Aged Aged 80 and over Centrosome Oncogene biology Gene Expression Regulation Leukemic Myeloid leukemia Cancer General Medicine Middle Aged medicine.disease Molecular medicine Immunity Humoral Neoplasm Proteins 030104 developmental biology Imatinib mesylate Oncology 030220 oncology & carcinogenesis Case-Control Studies Immunology biology.protein Female Antibody |
| Zdroj: | Oncology reports. 37(1) |
| ISSN: | 1791-2431 |
| Popis: | As the extent of centrosome abnormalities in chronic myeloid leukemia (CML) correlates with disease stage and karyotype alterations, abnormal expression of genes encoding centrosomal proteins may be an early prognostic marker of disease progression. In the present study, we showed that in comparison with healthy controls, the expression of four centrosomal genes (AURKA, HMMR, PLK1 and ESPL1) in the peripheral blood of CML patients was significantly enhanced at diagnosis and decreased to the basal level in most patients treated with imatinib mesylate for three months. In the remaining patients (17%), this decrease was delayed and was associated with worse overall survival. The detection of antibodies in sera showed that patients with higher overall antibody production had superior outcomes in terms of achieving major molecular response and failure-free survival. These data suggest that the dynamics of the response of centrosomal genes should be considered as a risk factor and immunity against centrosomal proteins may contribute to treatment response. |
| Databáze: | OpenAIRE |
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