Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells
| Autor: | Gord Fishell, Thomas Gridley, Heather A. Mason, Todd E. Anthony, Nathaniel Heintz |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Central Nervous System
Indoles Notch signaling pathway Fluorescent Antibody Technique Mice Transgenic Nerve Tissue Proteins Biology Fatty Acid-Binding Proteins Research Communications Mice Genetics medicine Animals Nuclear protein Promoter Regions Genetic Binding Sites Base Sequence Receptors Notch Histocytochemistry Effector Binding protein Gene Expression Regulation Developmental Membrane Proteins Nuclear Proteins Galactosides FABP7 Molecular biology Cell biology DNA-Binding Proteins medicine.anatomical_structure nervous system Notch proteins Immunoglobulin J Recombination Signal Sequence-Binding Protein Neuroglia Signal transduction Carrier Proteins Fatty Acid-Binding Protein 7 Signal Transduction Developmental Biology |
| Zdroj: | Genes & Development. 19:1028-1033 |
| ISSN: | 1549-5477 0890-9369 |
| Popis: | Radial glia function during CNS development both as neural progenitors and as a scaffolding supporting neuronal migration. To elucidate pathways involved in these functions, we mapped in vivo the promoter for Blbp, a radial glial gene. We show here that a binding site for the Notch effector CBF1 is essential for all Blbp transcription in radial glia, and that BLBP expression is significantly reduced in the forebrains of mice lacking the Notch1 and Notch3 receptors. These results identify Blbp as the first predominantly CNS-specific Notch target gene and suggest that it mediates some aspects of Notch signaling in radial glia. |
| Databáze: | OpenAIRE |
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