Structural characterization and dissolution profile of mycophenolic acid cocrystals
| Autor: | Shuo Zhang, Jian Ouyang, Qing-Zhu Zeng, Lei Zhang |
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| Rok vydání: | 2016 |
| Předmět: |
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Molecular Niacinamide Carboxylic acid Inorganic chemistry Evaporation Pharmaceutical Science 02 engineering and technology 010402 general chemistry 01 natural sciences Cocrystal chemistry.chemical_compound 2 2'-Dipyridyl X-Ray Diffraction Isonicotinamide Dissolution chemistry.chemical_classification Calorimetry Differential Scanning Molecular Structure Hydrogen bond Hydrogen Bonding Hydrogen-Ion Concentration Mycophenolic Acid 021001 nanoscience & nanotechnology 0104 chemical sciences Drug Liberation chemistry Polymerization Solubility Slurry Minoxidil Powders 0210 nano-technology Crystallization Powder Diffraction Nuclear chemistry |
| Zdroj: | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 102 |
| ISSN: | 1879-0720 |
| Popis: | Three novel cocrystals of mycophenolic acid (MPA) with isonicotinamide (MPA-ISO), minoxidil (MPA-MIN) and 2,2'-dipyridylamine (MPA-DPA) as coformers have been prepared successfully by both slow evaporation and liquid-assisted grinding. The structures of these cocrystals show that all the three coformers form hydrogen bonds with the carboxylic acid group of MPA. The cocrystal MPA-ISO possesses remarkably improved solubility and dissolution rate, while two other cocrystals exhibit the opposite characteristics. The solids in the slurry with pH6.8 phosphate buffer and cocrystals remain as the incipient cocrystal after 24h. However, evidence of slight polymerization was shown in the slurry of pH6.8 phosphate buffer with MPA and MPA-ISO cocrystal. |
| Databáze: | OpenAIRE |
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