Characterization of acute myeloid leukemia based on levels of global hydroxymethylation

Autor: Kroeze, L.I., Aslanyan, M.G., Rooij, A. van, Koorenhof-Scheele, T.N., Massop, M., Carell, T., Boezeman, J.B., Marie, J.P., Halkes, C.J.M., Witte, T. de, Huls, G., Suciu, S., Wevers, R.A., Reijden, B.A. van der, Jansen, J.H., EORTC Leukemia Grp, GIMEMA
Rok vydání: 2014
Předmět:
Adult
Oncology
medicine.medical_specialty
IDH1
Adolescent
Cancer development and immune defence Radboud Institute for Molecular Life Sciences [Radboudumc 2]
DNA Mutational Analysis
Immunology
Biology
Biochemistry
IDH2
DNA Methyltransferase 3A
Dioxygenases
Cytosine
Young Adult
Proto-Oncogene Proteins
Internal medicine
medicine
Humans
Disorders of movement Radboud Institute for Molecular Life Sciences [Radboudumc 3]
DNA (Cytosine-5-)-Methyltransferases
Young adult
Promoter Regions
Genetic
Survival analysis
Aged
Hazard ratio
Cancer
Myeloid leukemia
Cell Biology
Hematology
DNA Methylation
Middle Aged
Prognosis
medicine.disease
Survival Analysis
Isocitrate Dehydrogenase
DNA-Binding Proteins
Leukemia
Leukemia
Myeloid
Acute Disease
Mutation
5-Methylcytosine
Inflammatory diseases Radboud Institute for Molecular Life Sciences [Radboudumc 5]
Zdroj: Blood, 124, 7, pp. 1110-8
Blood, 124, 1110-8
Blood, 124(7), 1110-1118
ISSN: 1528-0020
0006-4971
DOI: 10.1182/blood-2013-08-518514
Popis: Contains fulltext : 137617.pdf (Publisher’s version ) (Closed access) Patients with acute myeloid leukemia (AML) frequently harbor mutations in genes involved in the DNA (hydroxy)methylation pathway (DNMT3A, TET2, IDH1, and IDH2). In this study, we measured 5-hydroxymethylcytosine (5hmC) levels in 206 clinically and molecularly well-characterized younger adult AML patients (
Databáze: OpenAIRE
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