Dendritic cell migration in health and disease
| Autor: | Tim Worbs, Swantje I. Hammerschmidt, Reinhold Förster |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
History Chemokine Autoimmunity Disease medicine.disease_cause Education Immune tolerance Pathogenesis 03 medical and health sciences 0302 clinical medicine Immune system Cell Movement Immune Tolerance medicine Animals Humans Dendritic cell migration Tissue homeostasis biology Dendritic Cells Computer Science Applications 030104 developmental biology Immunology biology.protein 030215 immunology |
| Zdroj: | Nature Reviews Immunology. 17:30-48 |
| ISSN: | 1474-1741 1474-1733 |
| Popis: | Dendritic cells (DCs) are potent and versatile antigen-presenting cells, and their ability to migrate is key for the initiation of protective pro-inflammatory as well as tolerogenic immune responses. Recent comprehensive studies have highlighted the importance of DC migration in the maintenance of immune surveillance and tissue homeostasis, and also in the pathogenesis of a range of diseases. In this Review, we summarize the anatomical, cellular and molecular factors that regulate the migration of different DC subsets in health and disease. In particular, we focus on new insights concerning the role of migratory DCs in the pathogenesis of diseases of the skin, intestine, lung, and brain, as well as in autoimmunity and atherosclerosis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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