Apoptotic Bodies of Cardiomyocytes and Fibroblasts — Regulators of Directed Differentiation of Heart Stem Cells
| Autor: | S V Rad'ko, N A Knyazev, S V Suchkov, Alexey A. Bogdanov, Е А Zakharov, G B Belostotskaya, Vladimir V. Klimenko, D. Yu. Ivkin, A. I. Tyukavin |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Aging Programmed cell death Primary Cell Culture Cardiomyopathy Angiotensin-Converting Enzyme Inhibitors Apoptosis General Biochemistry Genetics and Molecular Biology Contractility Extracellular Vesicles 03 medical and health sciences 0302 clinical medicine Directed differentiation medicine Animals Myocytes Cardiac Rats Wistar Chemistry Myocardium Stem Cells Regeneration (biology) RNA Cell Differentiation General Medicine Fibroblasts medicine.disease Myocardial Contraction Clone Cells Culture Media Rats Cell biology 030104 developmental biology Doxorubicin Fosinopril Stem cell Cardiomyopathies 030217 neurology & neurosurgery Signal Transduction |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 170:112-117 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-020-05015-0 |
| Popis: | We studied the effects of apoptotic bodies of cardiomyocytes (ApBc) and fibroblasts (ApBf) on myocardial regeneration and contractility in rats and the dynamics of RNA concentrations in cardiomyocytes and fibroblasts at different stages of apoptosis. ApBc increase the contractility of rat myocardium, while ApBf reduce it. ApBc stimulate the development of clones of cardiomyocyte precursors in the myocardium, while ApBf stimulate the formation of endothelial precursor clones. In doxorubicin cardiomyopathy, ApBc, similar to the reference drug (ACE inhibitor) improve animal survival, while ApBf produce no such effect. RNA concentrations in cardiomyocytes and fibroblasts before apoptosis and at the beginning of cell death significantly differed, while in apoptotic bodies of these cells, it was practically the same. It has been hypothesized that RNA complex present in ApBc and ApBf represents an "epigenetic code" of directed differentiation of cardiac stem cells. |
| Databáze: | OpenAIRE |
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