HtrA1: a novel regulator of physiological and pathological matrix mineralization?
| Autor: | Fiona L. Wilkinson, Kristen D. Hadfield, Claire Farrington Rock, E.C. Wylie, Ann E. Canfield |
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| Rok vydání: | 2007 |
| Předmět: |
biology
Decorin Serine Endopeptidases Regulator Osteoblast Bacterial Physiological Phenomena High-Temperature Requirement A Serine Peptidase 1 Bone morphogenetic protein Biochemistry eye diseases In vitro Extracellular Matrix medicine.anatomical_structure HTRA1 Matrix gla protein biology.protein medicine Animals Humans |
| Zdroj: | Biochemical Society transactions. 35(Pt 4) |
| ISSN: | 0300-5127 |
| Popis: | HtrA1 (high-temperature requirement protein A1) is a secreted multidomain protein with proven serine protease activity and the ability to regulate TGF-β (transforming growth factor-β)/BMP (bone morphogenetic protein) signalling. There is increasing evidence that HtrA1 regulates several pathological processes, including tumour development, Alzheimer's disease, age-related macular degeneration and osteoarthritis, although the mechanism(s) by which it regulates these processes have not been fully elucidated. Using overexpression and knock-down strategies, we have evidence demonstrating that HtrA1 is also a key regulator of physiological and pathological matrix mineralization in vitro. We propose that HtrA1 regulates mineralization by inhibiting TGF-β/BMP signalling and/or by cleaving specific matrix proteins, including decorin and MGP (matrix Gla protein). Taken together, these studies suggest that HtrA1 may be a novel therapeutic target for several diseases. |
| Databáze: | OpenAIRE |
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