Field effectiveness of highly pathogenic avian influenza H5N1 vaccination in commercial layers in Indonesia
| Autor: | Risa Indriani, Syafrison Idris, Michael Haryadi Wibowo, Mark Stevenson, Widya Asmara, Jagoda Ignjatovic, Peter A. Durr, Esmaeil Ebrahimie, Sidna Artanto, Simson Tarigan, Sumarningsih Sumarningsih |
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| Přispěvatelé: | Tarigan, Simson, Wibowo, Michael Haryadi, Indriani, Risa, Sumarningsih, Sumarningsih, Artanto, Sidna, Idris, Syafrison, Durr, Peter A, Asmara, Widya, Ebrahimie, Esmaeil, Stevenson, Mark A, Ignjatovic, Jagoda |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
RNA viruses
0301 basic medicine Veterinary medicine Hemagglutination Physiology animal diseases lcsh:Medicine Antibodies Viral medicine.disease_cause Biochemistry Poultry law.invention Geographical Locations 0403 veterinary science law Zoonoses Immune Physiology Medicine and Health Sciences Influenza A virus Public and Occupational Health Longitudinal Studies Prospective Studies Treatment Failure Animal Husbandry lcsh:Science Pathology and laboratory medicine Vaccines Immune System Proteins Multidisciplinary Viral Vaccine Eukaryota H5N1 04 agricultural and veterinary sciences Medical microbiology Vaccination and Immunization Vaccination Infectious Diseases Transmission (mechanics) Influenza Vaccines Vertebrates Viruses hemagglutination inhibiting antibody Pathogens Research Article Asia Infectious Disease Control 040301 veterinary sciences Immunology Oceania Biology Microbiology Antibodies Birds 03 medical and health sciences Immunity medicine Animals Influenza viruses Poultry Diseases Influenza A Virus H5N1 Subtype lcsh:R Organisms Viral pathogens Biology and Life Sciences Proteins Hemagglutination Inhibition Tests Influenza A virus subtype H5N1 Microbial pathogens 030104 developmental biology Indonesia Influenza in Birds Amniotes People and Places lcsh:Q Preventive Medicine Flock influenza vaccine Chickens Orthomyxoviruses |
| Zdroj: | PLoS ONE, Vol 13, Iss 1, p e0190947 (2018) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Although vaccination of poultry for control of highly pathogenic avian influenza virus (HPAIV) H5N1 has been practiced during the last decade in several countries, its effectiveness under field conditions remains largely unquantified. Effective HPAI vaccination is however essential in preventing incursions, silent infections and generation of new H5N1 antigenic variants. The objective of this study was to asses the level and duration of vaccine induced immunity in commercial layers in Indonesia. Titres of H5N1 haemagglutination inhibition (HI) antibodies were followed in individual birds from sixteen flocks, age 18–68 week old (wo). The study revealed that H5N1 vaccination had highly variable outcome, including vaccination failures, and was largely ineffective in providing long lasting protective immunity. Flocks were vaccinated with seven different vaccines, administer at various times that could be grouped into three regimes: In regime A, flocks (n = 8) were vaccinated two or three times before 19 wo; in regime B (n = 2), two times before and once after 19 wo; and in regime C (n = 6) three to four times before and two to three times after 19 wo. HI titres in regime C birds were significantly higher during the entire observation period in comparison to titres of regime A or B birds, which also differed significantly from each other. The HI titres of individual birds in each flock differed significantly from birds in other flocks, indicating that the effectiveness of field vaccination was highly variable and farm related. Protective HI titres of > 4log 2, were present in the majority of flocks at 18 wo, declined thereafter at variable rate and only two regime C flocks had protective HI titres at 68 wo. Laboratory challenge with HPAIV H5N1 of birds from regime A and C flocks confirmed that protective immunity differed significantly between flocks vaccinated by these two regimes. The study revealed that effectiveness of the currently applied H5N1 vaccination could be improved and measures to achieve this are discussed. Refereed/Peer-reviewed |
| Databáze: | OpenAIRE |
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