Corrected cerebral blood flow and reduced cerebral inflammation in berk sickle mice with higher fetal hemoglobin

Autor:	Min-Hui Cui, Henny H. Billett, Sandra M. Suzuka, Kamalakar Ambadipudi, Seetharama Archarya, Wenzhu B. Mowrey, Craig A. Branch
Rok vydání:	2021
Předmět:	Inflammation Oxygen Mice Diffusion Tensor Imaging Physiology (medical) Cerebrovascular Circulation Biochemistry (medical) Hemoglobin Sickle Public Health Environmental and Occupational Health Animals General Medicine Anemia Sickle Cell Fetal Hemoglobin
Zdroj:	Translational research : the journal of laboratory and clinical medicine. 244
ISSN:	1878-1810
Popis:	Fetal hemoglobin (HbF) is known to lessen the severity of sickle cell disease (SCD), through reductions in peripheral vaso-occlusive disease and reduced risk for cerebrovascular events. However, the influence of HbF on oxygen delivery to high metabolism tissues like the brain, or its influence on cerebral perfusion, metabolism, inflammation or function have not been widely studied. We employed a Berkley mouse model (BERK) of SCD with gamma transgenes q3 expressing exclusively human α- and β
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::910099255cedbbd2bc5c9db55df672bb https://pubmed.ncbi.nlm.nih.gov/35091127 Zobrazit plný text záznamu Full Text from ScienceDirect