Engineering next-generation bioinks with nanoparticles: moving from reinforcement fillers to multifunctional nanoelements
| Autor: | Syeda Mahwish Bakht, Alberto Pardo, Rui L. Reis, Manuel Gómez-Florit, Rui M. A. Domingues, Manuela E. Gomes |
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| Přispěvatelé: | Universidade do Minho |
| Rok vydání: | 2021 |
| Předmět: |
Computer science
Multifunctional nanoparticles Biomedical Engineering Nanoparticle Biocompatible Materials Nanotechnology Bioprinting In vitro models 02 engineering and technology 010402 general chemistry 01 natural sciences Humans Engenharia dos Materiais [Engenharia e Tecnologia] General Materials Science Science & Technology Tissue Engineering Nanocomposite hydrogels Hydrogels General Chemistry General Medicine 021001 nanoscience & nanotechnology 0104 chemical sciences Engenharia e Tecnologia::Engenharia dos Materiais Scientific development Nanoparticles Ink 0210 nano-technology |
| Zdroj: | Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP |
| ISSN: | 2050-7518 2050-750X |
| Popis: | The application of additive manufacturing in the biomedical field has become a hot topic in the last decade owing to its potential to provide personalized solutions for patients. Different bioinks have been designed trying to obtain a unique concoction that addresses all the needs for tissue engineering and drug delivery purposes, among others. Despite the remarkable progress made, the development of suitable bioinks which combine printability, cytocompatibility, and biofunctionality is still a challenge. In this sense, the well-established synthetic and functionalization routes to prepare nanoparticles with different functionalities make them excellent candidates to be combined with polymeric systems in order to generate suitable multi-functional bioinks. In this review, we briefly discuss the most recent advances in the design of functional nanocomposite hydrogels considering their already evaluated or potential use as bioinks. The scientific development over the last few years is reviewed, focusing the discussion on the wide range of functionalities that can be incorporated into 3D bioprinted constructs through the addition of multifunctional nanoparticles in order to increase their regenerative potential in the field of tissue engineering. Authors acknowledge financial support from the ERC Grant CoG MagTendon nr 772817; FCT – Fundação para a Ciência e a Tecnologia for the PhD grant of SMB (PD/BD/129403/2017), for the contract to MGF (CEECIND/01375/2017); and for project SmarTendon (PTDC/NAN-MAT/30595/2017). AP is grateful to Xunta de Galicia for his postdoctoral grant ED481B2019/025. Some figures were created with BioRender.com. |
| Databáze: | OpenAIRE |
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