Neurochemical impact of bisphenol A in the hippocampus and cortex of adult male albino rats

Autor: Heba S. Aboul Ezz, Iman M. Mourad, Neveen A. Noor, Yasser A. Khadrawy
Rok vydání: 2016
Předmět:
Male
0301 basic medicine
endocrine system
medicine.medical_specialty
Taurine
Health
Toxicology and Mutagenesis
Hippocampus
Endocrine Disruptors
Nitric Oxide
Toxicology
Synaptic Transmission
Lipid peroxidation
Random Allocation
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Phenols
Internal medicine
medicine
Animals
Benzhydryl Compounds
Rats
Wistar
Brain Chemistry
Cerebral Cortex
Neurons
chemistry.chemical_classification
Dose-Response Relationship
Drug
urogenital system
Chemistry
Toxicity Tests
Subchronic
Public Health
Environmental and Occupational Health
Glutamate receptor
Glutathione
Amino acid
Oxidative Stress
030104 developmental biology
Endocrinology
Organ Specificity
Amino acid neurotransmitter
Glycine
Environmental Pollutants
Neurotoxicity Syndromes
Lipid Peroxidation
Oxidation-Reduction
Biomarkers
hormones
hormone substitutes
and hormone antagonists
030217 neurology & neurosurgery
Zdroj: Toxicology and Industrial Health. 32:1711-1719
ISSN: 1477-0393
0748-2337
DOI: 10.1177/0748233715579803
Popis: Bisphenol A (BPA), an endocrine-disrupting chemical, is widely used in the manufacture of polycarbonated plastics and epoxy resins and line metal beverage cans. Growing evidence suggests that BPA acts directly on neuronal functions as it is lipophilic and could accumulate in the brain. The present study aims to investigate the effect of two doses of BPA (10 mg/kg for 6 and 10 weeks and 25 mg/kg for 6 weeks) on excitatory (glutamate and aspartate) and inhibitory (γ-aminobutyric acid, glycine, and taurine) amino acid neurotransmitter levels in the cortex and hippocampus. This study extends to investigate the effect of BPA on acetylcholinesterase (AchE) activity and some oxidative stress parameters in the two regions. In the cortex, a significant increase in the excitatory and a significant decrease in the inhibitory amino acids occurred after BPA (10 mg/kg for 10 weeks and 25 mg/kg for 6 weeks). This was accompanied by a significant increase in lipid peroxidation, nitric oxide, and reduced glutathione after 6 weeks of BPA (25 mg/kg). In the hippocampus, a significant increase in the excitatory and inhibitory amino acid neurotransmitters occurred after 6 weeks of BPA. Hippocampal lipid peroxidation increased significantly after BPA exposure and hippocampal reduced glutathione increased significantly after 6 weeks of BPA exposure (10 mg/kg). BPA induced a significant increase in cortical and hippocampal AchE activity. The present neurochemical changes in the cortex and hippocampus suggest that BPA induced a state of excitotoxicity and oxidative stress. This may raise concerns about the exposure of humans to BPA due to its wide applications in industry.
Databáze: OpenAIRE
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