D-dimer concentrations in acute urticaria in children
| Autor: | Agnieszka Ochab, Anna Zaryczańska, Zenon Brzoza, Agata Chobot, Janusz Zaryczański, Magdalena Ochab |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine medicine.medical_specialty pediatrics Adolescent Urticaria Immunology D-dimers glucocorticosteroids Fibrin Fibrinogen Degradation Products 03 medical and health sciences 0302 clinical medicine children Ambulatory care Internal medicine White blood cell D-dimer Humans Immunology and Allergy Medicine Platelet In patient acute urticaria Child Glucocorticoids Retrospective Studies Acute urticaria Angioedema business.industry Disease Management Infant General Medicine medicine.anatomical_structure 030228 respiratory system Child Preschool Acute Disease Antihistaminic drugs Female medicine.symptom business Biomarkers 030215 immunology |
| Zdroj: | Allergologia et Immunopathologia. 49:107-112 |
| ISSN: | 0301-0546 |
| DOI: | 10.15586/aei.v49i1.30 |
| Popis: | Introduction: Urticaria is a clinical entity presenting as wheals, angioedema, or both simul-taneously. Elevated D-dimer levels were reported in the course of chronic spontaneous urticaria. Data regarding D-dimer levels in acute urticaria in children are limited. Objectives: To assess potential associations between duration of glucocorticosteroid (GCS) therapy and D-dimer concentrations in children with acute urticaria. Patients, materials, and methods: Hospital records of 106 children (59 females), aged 5.57 ± 4.91 years, hospitalized in 2014–2018 were analyzed retrospectively. The study group consisted of pediatric patients admitted to the hospital due to severe acute urticaria resistant to anti-histaminic treatment that was ordered in the ambulatory care (out-patient clinic). Patients were divided into subgroups: no GCS treatment, short-duration treatment (up to 5 days) and long-duration treatment (6 and more days) GCS treatment. Simultaneously, patients received antihistaminic drugs. D-dimer level and other inflammatory factors such as white blood cell (WBC) count, platelet (PLT) count, and C-reactive protein (CRP) in each group were analyzed. Results: The D-dimer level was elevated in 51% of cases. In the subgroup with longer GCS treatment, D-dimer concentration was significantly higher in comparison to patients with a shorter GCS course. There were no differences in the distribution of CRP, PLT, and WBC concentrations between these subgroups. Conclusions: In the studied group of children, there was a tendency for higher D-dimer levels in patients, who required a longer GCS treatment. This finding is hypothesis-generating and requires further investigation to confirm if D-dimers can be used as a prognostic factor in acute urticaria in children. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|