Mechanism of action of injection therapy for bleeding peptic ulcer
| Autor: | C. Rajgopal, A. Lessels, K. R. Palmer |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
medicine.medical_specialty
Necrosis Bleeding Time Epinephrine medicine.medical_treatment Injections chemistry.chemical_compound Ethanolamine medicine Animals Stomach Ulcer Saline business.industry Endarteritis medicine.disease Thrombosis Pathophysiology Surgery Venous thrombosis Disease Models Animal Peptic Ulcer Hemorrhage chemistry Ethanolamines Gastric Mucosa Anesthesia Tamponade Rabbits medicine.symptom business |
| Zdroj: | The British journal of surgery. 79(8) |
| ISSN: | 0007-1323 |
| Popis: | The effects of intramucosal injection of 1: 100 000 adrenaline, 5 per cent ethanolamine and normal saline were determined in experimentally created, acutely bleeding gastric mucosal wounds in rabbits. The mean(s.d.) bleeding rate was decreased from 2.3(0.4) to 0.2(0.02) ml/min by adrenaline (P < 0.01), but increased by 1 ml 5 per cent ethanolamine to 4.0(0.6) ml/min (P < 0.05). Normal saline had no haemostatic effect, suggesting that local tamponade is not important. In separate experiments endoscopic injections of 5 per cent ethanolamine, 1: 100 000 adrenaline and normal saline were made in the gastric antrum of rabbits. After 48 h the degree of inflammation was greatest with ethanolamine but, despite tissue necrosis and venous thrombosis, neither endarteritis nor arterial thrombosis occurred. Injections of 5 per cent ethanolamine and 80 per cent ethanol placed next to the ear arteries of rabbits caused local ulceration and necrosis, but endarteritis and arterial thrombosis were again absent. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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