One‐Pot Two‐Step Synthesis of Isochromene‐Fused CF 3 ‐Substituted Pyrazoles

Autor:	Peter Wipf, Života Selaković, Filip Živković, Igor Opsenica, Andrea Nikolic
Rok vydání:	2020
Předmět:	010405 organic chemistry Chemistry Isochromenes Organic Chemistry Two step C–F correlation Heterocycles 010402 general chemistry 01 natural sciences Combinatorial chemistry 0104 chemical sciences 3. Good health Pyrazoles Physical and Theoretical Chemistry Palladium
Zdroj:	European Journal of Organic Chemistry
ISSN:	1099-0690 1434-193X
DOI:	10.1002/ejoc.202000942
Popis:	An efficient one-pot, two step method for fusing two biologically active motifs, CF3-substituted pyrazoles and isochromenes, was developed. Selective O-benzylation of CF3-substituted pyrazolones and subsequent Pd-catalyzed direct C–H arylation generate a fused tricycle. For the synthesized compounds through-space 13C–19F spin–spin coupling was revealed. In addition, the synthesis of three thioisochromene analogues, and one isocoumarin derivative, was accomplished.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90bef3270a0f7e2f881ca3aa67408aba https://doi.org/10.1002/ejoc.202000942 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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