Staphylococcal adherence to polyvinyl chloride and heparin-bonded polyurethane catheters is species dependent and enhanced by fibronectin
| Autor: | Jane Kline, M C Yoder, Richard A. Polin, P B Russell |
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| Rok vydání: | 1987 |
| Předmět: |
Microbiology (medical)
Staphylococcus aureus Staphylococcus Polyurethanes medicine.disease_cause Bacterial Adhesion Catheterization Microbiology Sepsis chemistry.chemical_compound Catheters Indwelling Staphylococcus epidermidis medicine Humans Polyvinyl Chloride biology Heparin biology.organism_classification medicine.disease Fibronectins Fibronectin Microscopy Electron Polyvinyl chloride Catheter chemistry biology.protein Polyvinyls Research Article medicine.drug |
| Zdroj: | Journal of Clinical Microbiology. 25:1083-1087 |
| ISSN: | 1098-660X 0095-1137 |
| DOI: | 10.1128/jcm.25.6.1083-1087.1987 |
| Popis: | Intravenous hyperalimentation has improved the survival of premature infants. However, long-term placement of intravenous catheters may result in the development of catheter-related sepsis. Fibronectin in plasma contains binding sites for staphylococcal species as well as marked affinity for inert plastics and therefore may provide a substrate for bacterial adherence to indwelling catheters. We determined the adherence of labeled [( 3H]leucine) coagulase-positive (CPS) and coagulase-negative (CNS) staphylococci to untreated and fibronectin-coated polyvinyl chloride (PVC) and heparin-bonded polyurethane (HBP) catheter segments and quantitated the binding of 14C-labeled, purified fibronectin to these catheters. PVC catheter segments bound significantly more CNS than CPS (P less than 0.05), while HBP catheters bound more CPS than CNS (P less than 0.05). Fibronectin significantly increased the adherence of CPS to PVC catheters (P less than 0.05) and CNS to HBP catheters (P less than 0.05). PVC catheters bound more fibronectin (P less than 0.0001) than did HBP catheters. Catheter composition may influence the spectrum of nosocomial pathogens to which infants are susceptible through different bacterial adherences and interactions with adhesive proteins. |
| Databáze: | OpenAIRE |
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