Biochemical and clinical characterization of metabolic phenotypes: a cross-sectional study from Maracaibo city, Venezuela
| Autor: | Modesto Graterol, María Calvo, Juan Diego Hernández, Carlos Garicano, Joselyn Rojas, Roberto Añez, Luis Carlos Olivar, María Sofía Martínez, Andres Mindiola, Marcos Cerda, Juan Salazar, Sandra Wilches-Duran, Rosemily Graterol, Manuel Velasco, Valmore Bermúdez |
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| Rok vydání: | 2018 |
| Předmět: |
Cross-sectional study
viruses Population two-step cluster Physiology 030204 cardiovascular system & hematology Overweight General Biochemistry Genetics and Molecular Biology coronary risk 03 medical and health sciences 0302 clinical medicine Insulin resistance metabolically healthy obese medicine 030212 general & internal medicine General Pharmacology Toxicology and Pharmaceutics education education.field_of_study Metabolic phenotypes General Immunology and Microbiology business.industry virus diseases Articles General Medicine biochemical phenomena metabolism and nutrition medicine.disease Obesity digestive system diseases metabolically unhealthy lean Basal (medicine) medicine.symptom Metabolic syndrome business Dyslipidemia Research Article |
| Zdroj: | F1000Research |
| ISSN: | 2046-1402 |
| DOI: | 10.12688/f1000research.13897.1 |
| Popis: | Background: In 1980, Reuben Andresen observed that in certain individuals, obesity did not increase mortality, introducing an atypical phenotype called “healthy obese”. Other studies reported that 10-15 % of lean individuals presented insulin resistance, hyperglycemia and dyslipidemia. The objective of this study was to evaluate biochemical and clinical characteristics of metabolic phenotypes in Maracaibo city. Methods: A descriptive, cross-sectional sub-analysis of The Maracaibo City Metabolic Syndrome Prevalence Study, with a randomized multistage sampling was performed including 1226 non diabetic individuals from both sexes. For phenotype definition, the subjects were first classified according to their BMI into Normal-Weight, Overweight and Obese; then divided in metabolically healthy and unhealthy using a two-step analysis cluster being predictive variables: HOMA2-IR, HOMA2-βcell, triglycerides. To evaluate the relationship with coronary risk, a multiple logistic regression model was performed. Results: In the studied population, 43.9% (n=538) were healthy normal weight, 5.2% (n=64) unhealthy normal weight, 17.4% (n=217) healthy obese and 33.5% (n=411) unhealthy obese subjects. Atypical phenotypes, Metabolically Unhealthy Normal-Weight (MUNW) was more frequent in males (56.3%), whereas Metabolically Unhealthy Obese (MUO) was more frequent in females (51.3%). This phenotypes had a higher coronary event risk, especially for obese individuals (MHO: OR=1.85 CI95%: 1.11-3.09; p=0.02 and MUO: OR=2.09 CI95%: 1.34-3.28; p Conclusion: Individuals with atypical metabolic phenotypes are common in Maracaibo city. Related factors may include insulin resistance, basal glucose, and triglycerides levels. Lastly, obese subjects show a higher coronary event risk even those with normal metabolic status. |
| Databáze: | OpenAIRE |
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