Two new monoterpenoid indole alkaloids from Alstonia rostrata
| Autor: | Xiao-Jiang Hao, Feng Guo, Yu Zhang, Hong-Ping He, Yu-Xi Yuan |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Monoterpenoid Indole Alkaloids
Magnetic Resonance Spectroscopy Stereochemistry HL-60 Cells Plant Science 01 natural sciences Biochemistry Analytical Chemistry Cell Line Tumor Humans Organic chemistry Indole test Molecular Structure Apocynaceae biology 010405 organic chemistry Chemistry Organic Chemistry Alstonia rostrata biology.organism_classification Antineoplastic Agents Phytogenic Secologanin Tryptamine Alkaloids 0104 chemical sciences 010404 medicinal & biomolecular chemistry MCF-7 Cells Drug Screening Assays Antitumor Alstonia Human cancer |
| Zdroj: | Natural Product Research. 32:844-848 |
| ISSN: | 1478-6427 1478-6419 |
| DOI: | 10.1080/14786419.2017.1360886 |
| Popis: | Two new indole alkaloids, winphyllines A (1) and B (4), along with four known alkaloids, Nb-demethylechitamine (2), 17-O-acetylnorechitamine (3), 12-methoxyechitamidine (5), and N(4)-demethylastogustine (6), were isolated from the methanol extract of the twigs of Alstonia rostrata. The structures of 1 and 4 were elucidated by means of HRMS and NMR spectroscopic methods. The in vitro cytotoxic activity of the isolated alkaloids against several human cancer cell lines was evaluated. |
| Databáze: | OpenAIRE |
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