Effect of alpha-adrenergic blockade on pituitary hormonal responses to insulin-induced hypoglycemia in humans
| Autor: | J. J. Morton, Peter H Baylis, C. E. Gray, Fisher Bm, D. A. Hepburn, Thornton S, Frier Bm, Beastall Gh |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Male medicine.medical_specialty Vasopressin Endocrinology Diabetes and Metabolism medicine.medical_treatment Neuropeptide Biology Peptide hormone Hypoglycemia Oxytocin Endocrinology Phentolamine Adrenocorticotropic Hormone Internal medicine medicine Humans Insulin Adrenergic alpha-Antagonists General Medicine medicine.disease Prolactin Arginine Vasopressin hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Acta endocrinologica. 125(4) |
| ISSN: | 0001-5598 |
| Popis: | Arginine vasopressin, oxytocin and ACTH are released from the pituitary gland in response to acute hypoglycemia. To investigate the role of α-adrenergic mechanisms in mediating this response, 6 non-diabetic subjects were studied during hypoglycemia induced by 0.15 IU/kg iv insulin under control conditions, and during non-selective α-adrenergic blockade with phentolamine. In the control study plasma arginine vasopressin rose from 1.6±0.8 pmol/l (mean ± sem) basally to a maximum of 2.5±0.8 pmol/l following hypoglycemia (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|