Interhemispheric interaction during childhood: II. Children with early-treated phenylketonuria
| Autor: | Marie T. Banich, Robert D. Steiner, Marsha J. Nortz, Alessandra M. Passarotti, Desirée A. White |
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| Rok vydání: | 2001 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Audiology Corpus callosum Task (project management) Corpus Callosum Discrimination Learning Reference Values Phenylketonurias Developmental and Educational Psychology medicine Reaction Time Humans Attention Child Dominance Cerebral Problem Solving Cerebral Cortex School age child Cognition Neuropsychology and Physiological Psychology El Niño Pattern Recognition Visual Female Psychology Neuroscience |
| Zdroj: | Developmental neuropsychology. 18(1) |
| ISSN: | 8756-5641 |
| Popis: | This study examined whether children with early-treated phenylketonuria (ETPKU) exhibited a disruption in communication between the hemispheres as a function of computational complexity (Banich & Belger, 1990; Belger & Banich, 1992, 1998) when compared to neurologically uncompromised children who were matched in age and IQ. This investigation was motivated by findings that phenylketonuria affects myelination of neurons, including those that make up the corpus callosum, the main neural conduit for interhemispheric interaction. Children performed 2 tasks: a less complex physical-identity task and a more complex name-identity task. For both tasks, we compared performance on across-hemisphere trials, which require interhemispheric interaction, and on within-hemisphere trials, in which no hemispheric interaction is required. On the more complex name-identity task, children with ETPKU exhibited less of a benefit from across-hemisphere processing than did neurologically intact children. These results suggest that the interhemispheric interaction required to complete computationally complex tasks is compromised in children with ETPKU. Such an insufficiency may explain some of the attentional deficits observed in this group of children. |
| Databáze: | OpenAIRE |
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