Redefining Noradrenergic Neuromodulation of Behavior:Impacts of a Modular Locus Coeruleus Architecture
| Autor: | Anthony E. Pickering, Daniel J. Chandler, Lindsay A. Schwarz, Nelson K Totah, Patricia Jensen, Jordan G. McCall |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Adrenergic Neurons Pain Sensory system Biology 03 medical and health sciences Executive Function stress 0302 clinical medicine Salience (neuroscience) Neural Pathways medicine Animals Humans pain Wakefulness development Neurons business.industry locus coeruleus General Neuroscience Symposium and Mini-Symposium Modular design Neurophysiology 030104 developmental biology medicine.anatomical_structure executive function Forebrain Locus coeruleus Locus Coeruleus Nerve Net business Sleep Nucleus Neuroscience 030217 neurology & neurosurgery Anaesthesia Pain and Critical Care |
| Zdroj: | Chandler, D J, Jensen, P, McCall, J G, Pickering, A E, Schwarz, L A & Totah, N K 2019, ' Redefining Noradrenergic Neuromodulation of Behavior : Impacts of a Modular Locus Coeruleus Architecture ', Journal of Neuroscience, vol. 39, no. 42, pp. 8239-8249 . https://doi.org/10.1523/JNEUROSCI.1164-19.2019 The Journal of Neuroscience |
| DOI: | 10.1523/JNEUROSCI.1164-19.2019 |
| Popis: | The locus coeruleus (LC) is a seemingly singular and compact neuromodulatory nucleus that is a prominent component of disparate theories of brain function due to its broad noradrenergic projections throughout the CNS. As a diffuse neuromodulatory system, noradrenaline affects learning and decision making, control of sleep and wakefulness, sensory salience including pain, and the physiology of correlated forebrain activity (ensembles and networks) and brain hemodynamic responses. However, our understanding of the LC is undergoing a dramatic shift due to the application of state-of-the-art methods that reveal a nucleus of many modules that provide targeted neuromodulation. Here, we review the evidence supporting a modular LC based on multiple levels of observation (developmental, genetic, molecular, anatomical, and neurophysiological). We suggest that the concept of the LC as a singular nucleus and, alongside it, the role of the LC in diverse theories of brain function must be reconsidered. |
| Databáze: | OpenAIRE |
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