Claudin and occludin expression and function in the seminiferous epithelium
| Autor: | C. Yan Cheng, Carla M.K. Morrow, Rex A. Hess, Dolores D. Mruk |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Male
Tight junction urogenital system Articles Biology Occludin digestive system General Biochemistry Genetics and Molecular Biology Epithelium Cell biology Tight Junctions medicine.anatomical_structure Seminiferous Epithelium Claudins medicine Animals Humans General Agricultural and Biological Sciences Claudin Spermatogenesis Integral membrane protein tissues Function (biology) Blood–testis barrier |
| Popis: | Integral membrane proteins that contribute to function of the blood–testes barrier (BTB) in mice include claudins 3, 5 and 11 and occludin. Although claudin 11 is expressed throughout all stages of the seminiferous epithelial cycle, claudins 3 and 5 have specific expression at stage VIII. These differences in protein expression suggest that the interactions among, and functions of, these integral membrane proteins may shift over the course of the seminiferous epithelial cycle. Also, differences in expression among rodent species and men may make interpretation of studies across species challenging. This review will discuss the characteristics of claudins and occludin; the expression, regulation and function of these integral membrane proteins in the seminiferous epithelium; and how these properties relate to the unique features of BTB. |
| Databáze: | OpenAIRE |
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