Serum concentrations of neonicotinoids and their characteristic metabolites in elderly population from South China: Association with osteoporosis
| Autor: | Hua Zhang, Desheng Wang, Jiang Du, Guodong Sun, Jing Wang, Maota Ou, Junlong Hou, Wencai Zhang, Kairui Zhu |
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| Rok vydání: | 2021 |
| Předmět: |
Male
China Insecticides South china Osteoporosis Population Physiology Biochemistry Neonicotinoids Elderly population medicine Humans Adverse effect education General Environmental Science Aged education.field_of_study business.industry Data Collection Pest control Serum concentration Serum samples medicine.disease Female business |
| Zdroj: | Environmental research. 203 |
| ISSN: | 1096-0953 |
| Popis: | Neonicotinoids (NEOs) are extensively applied in global agricultural production for pest control but have adverse effects on human health. In this study, the concentrations of six NEOs and three characteristic metabolites were investigated by collecting 200 serum samples from an elderly population in China. Results showed that the NEOs and their metabolites were widely detected (89%-98 %) in the serum samples from the osteoporosis (OP) (n = 120) and non-OP (n = 80) population, and their median concentrations ranged from 0.04 ng/mL to 5.99 ng/mL and 0.01 ng/mL to 2.02 ng/mL, respectively. N-desmethyl-acetamiprid (ACE-dm) was the most abundant NEOs in the serum samples. Gender-related differences were found in concentrations of most NEOs and their metabolites in serum, with males having higher target analytes than females. Significantly (p 0.05) positive correlations were observed among most NEO concentrations, suggesting that exposure source of these substances is common or related. However, associations between the concentrations of characteristic metabolites and their corresponding NEOs were insignificant, probably because the exogenous intake are the primary sources of metabolites of NEOs instead of the internal biotransformation. The associations between NEO concentrations (i.e., ACE-dm, dinotefuran, and olefin-imidacloprid) and OP (OR = 2.33-6.92, 95 % CI = 0.37-16.9, p-trend 0.05) indicate that NEO exposure is correlated with increased odds of prevalent OP. This study is the first to document the profiles of NEOs and their metabolites in serum samples collected from an elderly population in South China and examine the relationships between NEO exposure and OP. |
| Databáze: | OpenAIRE |
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