Plasma lipoprotein(a) levels and atherosclerotic renal artery stenosis in hypertensive patients

Autor: GianLuca Colussi, Cristiana Catena, Leonardo A. Sechi, Frine Capobianco, Francesca Nait
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Male
lcsh:Diseases of the circulatory (Cardiovascular) system
Homocysteine
medicine.medical_treatment
lcsh:RC870-923
Kidney Function Tests
Renovascular hypertension
chemistry.chemical_compound
Risk Factors
lcsh:Dermatology
Ischemic nephropathy
biology
Fibrinolysis
Medicine (all)
food and beverages
General Medicine
Lipoprotein(a)
Middle Aged
Nephrology
Hypertension
Cardiology
lipids (amino acids
peptides
and proteins)
Female
Prothrombotic state
Cardiology and Cardiovascular Medicine
medicine.medical_specialty
Renal Artery Obstruction
Renal function
Internal medicine
medicine
Humans
Aged
Hemostasis
business.industry
Atherosclerosis
Cross-Sectional Studies
biochemical phenomena
metabolism
and nutrition
lcsh:RL1-803
medicine.disease
lcsh:Diseases of the genitourinary system. Urology
carbohydrates (lipids)
chemistry
lcsh:RC666-701
biology.protein
Ischemic Nephropathy
business
Zdroj: Kidney & Blood Pressure Research, Vol 40, Iss 2, Pp 166-175 (2015)
Popis: Background/Aims: The contribution of emergent cardiovascular risk factors to atherosclerotic renal artery stenosis (ARAS) is debated. We investigated the relationship of lipoprotein(a) and prothrombotic factors with ARAS in hypertension. Methods: In 50 hypertensive patients with angiographic evidence of ARAS and 58 hypertensive patients who had comparable cardiovascular risk factor burden but no evidence of renovascular disease, we measured renal function, lipoprotein(a), homocysteine, and hemostatic-fibrinolytic markers. Results: Patients with ARAS were more frequently smokers and had longer duration of hypertension, heavier antihypertensive treatment, and worse renal function than controls. Lipoprotein(a) was higher in patients with ARAS than controls, whereas no differences were found in homocysteine and all hemostatic variables. Multivariate analysis showed that lipoprotein(a) was associated with ARAS independent of other confounders including renal function and history of coronary heart, cerebrovascular, and peripheral artery disease. Conclusion: Lipoprotein(a) might contribute to the development of ARAS and detection of elevated levels of this lipoprotein could raise the suspicion of renovascular disease in patients with high blood pressure.
Databáze: OpenAIRE
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