Clinical assessment of cardiac impairment favored by two-dimensional speckle tracking echocardiology in patients with systemic sclerosis
| Autor: | Tiangang Zhu, Jingyi Ren, Tian Liu, Haihong Yao, Feng Zhang, Yuhui Li, Dan Xu, Zixi Yi, Xia Zhang, Chun Li, Xintong Jiang, Ruyi Cai, Rong Mu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Ejection fraction Scleroderma Systemic Adolescent business.industry Heart Ventricles Heart Stroke Volume Logistic regression Ventricular Function Left Basal (phylogenetics) Exact test Ventricular Dysfunction Left medicine.anatomical_structure Rheumatology Ventricle Internal medicine Troponin I medicine Cardiology Humans Pharmacology (medical) In patient business Cause of death |
| Zdroj: | Rheumatology (Oxford, England). 61(6) |
| ISSN: | 1462-0332 |
| Popis: | Background Cardiac involvement is a major cause of death in SSc, while early detection remains a challenge. Objectives The purpose of this study was to investigate the prevalence and clinical implications of cardiac impairment in SSc. Methods Ninety-five consecutive SSc patients [55.6 (13.8) years old, 5.3 (8.1) years from diagnosis] were included in the study. Patients with heart diseases onset prior to SSc were excluded. All patients underwent two-dimensional speckle-tracking echocardiology (2D-STE) with measuring left and right ventricular global longitudinal strain (GLS/RGLS). Clinical manifestation, laboratory evaluation (CRP, cTnI, antibodies, etc.) and ECG were collected at the same time. Comparisons between the SSc subgroups (lcSSc and dcSSc) were performed using Student’s t-test, Mann–Whitney U or Fisher’s exact test. Binary logistic regression was applied to determine the independent effects of variables in cardiac impairment. Results Early left and right ventricular impairment measured by GLS and RGLS were detected in 22.1% and 24.2% of the SSc patients, respectively. In comparison, only 2.1% showed reduced left ventricular ejection fraction (LVEF). Impaired GLS was mainly observed in the basal and medial segments of anterior, lateral and posterior left ventricle walls, and more profound in dcSSc. Elevated CRP (OR 3.561 95% CI: 1.071, 11.839, P Conclusions Cardiac impairment is a common manifestation in SSc. Increasing awareness of early cardiac impairment is warranted with elevated CRP and dcSSc. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|